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Adult Diseases and Low-Grade Systemic Inflammation Have Their Origins in the Perinatal Period

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Molecular Basis of Health and Disease

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Abstract

It is evident from the discussion in the preceding chapters on various diseases/disorders that low-grade systemic inflammation plays a significant role in the pathobiology of obesity, hypertension, type 2 diabetes mellitus, dyslipidemia, atherosclerosis, coronary heart disease, cancer, aging, Alzheimer’s disease, schizophrenia, depression, dementia and even stroke (though this disease was not discussed in details, in general, it occurs as a result of underlying hypertension, diabetes mellitus, hyperlipidemia and hence, could be considered as a consequence of these diseases rather than as a separate disease entity). The presence of low-grade systemic inflammation as evidenced by increased plasma levels of CRP, IL-6, TNF-α, HMGB-1, MIF, ROS, iNO, and a concomitant decrease in anti-inflammatory cytokines such as IL-4, IL-10, IL-12, TGF-β, and anti-oxidants, and decreased plasma and tissue levels of various PUFAs such as AA, EPA, DHA, GLA, DGLA and their anti-inflammatory products such as lipoxins, resolvins, protectins and maresins may underlie all these diseases. Thus, an imbalance between pro- and anti-inflammatory molecules seems to be a common feature in these diseases. Thus, the molecular events in all these diseases are similar but the target tissues are different. This implies that methods designed to suppress the production of pro-inflammatory molecules and/or increase in the synthesis and secretion of anti-inflammatory molecules could be of benefit in their prevention and management (Fig. 16.1).

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  1. UND Life Science, 13800 Fairhill Road, #321, 44120, Shaker Heights, OH, USA

    Undurti N. Das

  2. School of Biotechnology, Jawaharlal Nehru Technological University, 533003, Kakinada, India

    Undurti N. Das

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  1. Undurti N. Das
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© 2011 Springer Netherlands

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Das, U.N. (2011). Adult Diseases and Low-Grade Systemic Inflammation Have Their Origins in the Perinatal Period. In: Molecular Basis of Health and Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0495-4_16

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