Abstract
Probiotics are useful in mild enteric disorders that are limited to the presence of individual symptoms such as diarrhoea, constipation, and bloating. More controversial is their use in colonic diverticular disease or in one of the most common disorders, namely the irritable bowel syndrome. With few exceptions and in a limited well defined patients’ group, no evidence exists that probiotics induce and maintain remission in patients with inflammatory bowel disease. In this chapter we review the current evidence of the value of probiotics in clinical practice of the following enteric disorders as well as the formulations and compositions of specific probiotics. It will be clear that most of the compositions used are not classified as medicaments, and most of them are free to obtain as “over-the-counter” preparations administered without medical prescriptions. Therefore, their use as therapeutics is very limited at present. This situation is likely to change in coming years. As shown in other chapters of this book a multidisciplinary approach is bringing scientific protocols to the field of probiotics and new technology to study the complicated field of gut microbiology and ecology is being applied to the study of functional and inflammatory diseases of the gut.
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References
Barbara G, Cremon C, Pallotti F, De Giorgio R, Stanghellini V, Corinaldesi R (2009) Postinfectious irritable bowel syndrome. J Pediatr Gastroenterol Nutr 48(Suppl 2):S95–97 (Apr)
Bishop R (1999) Ruth Bishop: rotaviruses and vaccines. Interview by Amanda Tattam. Lancet 353(9167):1860 (May)
Bogardus ST Jr (2006) What do we know about diverticular disease? A brief overview. J Clin Gastroenterol 40(Suppl 3):S108–S111 (Aug)
Brigidi P, Vitali B, Swennen E, Bazzocchi G, Matteuzzi D (2001) Effects of probiotic administration upon the composition and enzymatic activity of human faecal microbiota in patients with irritable bowel syndrome or functional diarrhoea. Res Microbiol 152(8):735–741 (Oct)
Byrne CM, Clyne M, Bourke B (2007) Campylobacter jejuni adhere to and invade chicken intestinal epithelial cells in vitro. Microbiology 153(Pt 2):561–569 (Feb)
Campieri M, Gionchetti P (1999) Probiotics in inflammatory bowel disease: new insight to pathogenesis or a possible therapeutic alternative? Gastroenterology 116(5):1246–1249 (May)
Campieri M, Rizzello F, Venturi A, Poggioli G, Ugolini F, Helwig U et al (2000) Combination of antibiotic and probiotic treatment is efficacious in prophylaxis of post-operative recurrence of crohn’s disease: a randomized controlled study vs Mesalamine. Gastroenterology 118(4179):A781
Comparato G, Pilotto A, Franze A, Franceschi M, Di Mario F (2007) Diverticular disease in the elderly. Dig Dis 25(2):151–159
Cremonini F, Di Caro S, Nista EC, Bartolozzi F, Capelli G, Gasbarrini G et al (2002) Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhoea. Aliment Pharmacol Ther 16(8):1461–1467 (Aug)
Crushell E, Harty S, Sharif F, Bourke B (2004) Enteric campylobacter: purging its secrets? Pediatr Res 55(1):3–12 (Jan)
Cuomo R, Savarese MF, Gargano R (2007) Almost all irritable bowel syndromes are post-infectious and respond to probiotics: consensus issues. Dig Dis 25(3):241–244
Dendukuri N, Costa V, McGregor M, Brophy JM (2005) Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhoea: a systematic review. Can Med Assoc J 173(2):167–170 (19 July)
De Paula JA, Carmuega E, Weill R (2008) Effect of the ingestion of a symbiotic yogurt on the bowel habits of women with functional constipation. Acta Gastroenterol Latinoam 38(1):16–25 (Mar)
Duffy LC, Zielezny MA, Riepenhoff-Talty M, Dryja D, Sayahtaheri-Altaie S, Griffiths E et al (1994) Effectiveness of Bifidobacterium bifidum in mediating the clinical course of murine rotavirus diarrhoea. Pediatr Res 35(6):690–695 (June)
Fric P, Zavoral M (2003) The effect of non-pathogenic Escherichia coli in symptomatic uncomplicated diverticular disease of the colon. Eur J Gastroenterol Hepatol 15(3):313–315 (Mar)
Garcia Rodriguez LA, Ruigomez A, Panes J (2006) Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease. Gastroenterology 130(6):1588–1594 (May)
Gawronska A, Dziechciarz P, Horvath A, Szajewska H (2007) A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain disorders in children. Aliment Pharmacol Ther 25(2):177–184 (15 Jan)
Gibson GR, Roberfroid MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125(6):1401–1412 (June)
Gionchetti P, Rizzello F, Venturi A, Brigidi P, Matteuzzi D, Bazzocchi G et al (2000) Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gastroenterology 119(2):305–309 (Aug)
Gionchetti P, Rizzello F, Helwig U, Venturi A, Lammers KM, Brigidi P et al (2003) Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology 124(5):1202–1209 (May)
Gorbach SL, Chang TW, Goldin B (1987) Successful treatment of relapsing Clostridium difficile colitis with Lactobacillus GG. Lancet 2(8574):1519 (26 Dec)
Guandalini S (2002) Use of Lactobacillus-GG in paediatric Crohn’s disease. Dig Liver Dis 34(Suppl 2):S63–S65 (Sept)
Guslandi M, Giollo P, Testoni PA (2003) A pilot trial of Saccharomyces boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol 15(6):697–698 (June)
Hjern F, Johansson C, Mellgren A, Baxter NN, Hjern A (2006) Diverticular disease and migration—the influence of acculturation to a Western lifestyle on diverticular disease. Aliment Pharmacol Ther 23(6):797–805 (15 Mar)
Hoveyda N, Heneghan C, Mahtani KR, Perera R, Roberts N, Glasziou P (2009) A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome. BMC Gastroenterol 9:15
Isolauri E, Kaila M, Mykkanen H, Ling WH, Salminen S (1994) Oral bacteriotherapy for viral gastroenteritis. Dig Dis Sci 39(12):2595–2600 (Dec)
Jun S, Stollman N (2002) Epidemiology of diverticular disease. Best Pract Res Clin Gastroenterol 16(4):529–542 (Aug)
Kalischuk LD, Inglis GD, Buret AG (2007) Strain-dependent induction of epithelial cell oncosis by Campylobacter jejuni is correlated with invasion ability and is independent of cytolethal distending toxin. Microbiology 153(Pt 9):2952–2963 (Sept)
Katz JA (2003) Prevention is the best defense: probiotic prophylaxis of pouchitis. Gastroenterology 124(5):1535–1538 (May)
Kim HJ, Camilleri M, McKinzie S, Lempke MB, Burton DD, Thomforde GM et al (2003) A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 17(7):895–904 (1 Apr)
King TS, Elia M, Hunter JO (1998) Abnormal colonic fermentation in irritable bowel syndrome. Lancet 352(9135):1187–1189 (10 Oct)
Karimi O, Pena AS (2003) Probiotics: isolated bacteria strain or mixtures of different strains? Two different approaches in the use of probiotics as therapeutics. Drugs Today 39(8):565–597 (Aug)
Koebnick C, Wagner I, Leitzmann P, Stern U, Zunft HJ (2003) Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation. Can J Gastroenterol 17(11):655–659 (Nov)
Kruis W, Fric P, Pokrotnieks J, Lukas M, Fixa B, Kascak M et al (2004) Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 53(11):1617–1623 (Nov)
Kuisma J, Mentula S, Jarvinen H, Kahri A, Saxelin M, Farkkila M (2003) Effect of Lactobacillus rhamnosus GG on ileal pouch inflammation and microbial flora. Aliment Pharmacol Ther 17(4):509–515 (15 Feb)
Ludeman L, Warren BF, Shepherd NA (2002) The pathology of diverticular disease. Best Pract Res Clin Gastroenterol 16(4):543–562 (Aug)
Madden JA, Hunter JO (2002) A review of the role of the gut microflora in irritable bowel syndrome and the effects of probiotics. Br J Nutr 88 (Suppl 1):S67–S72 (Sept)
Marshall JK, Thabane M, Garg AX, Clark WF, Salvadori M, Collins SM (2006) Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysentery. Gastroenterology 131(2):445–450, quiz 660 (Aug)
Marteau P, Lemann M, Seksik P, Laharie D, Colombel JF, Bouhnik Y et al (2006) Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn’s disease: a randomised, double blind, placebo controlled GETAID trial. Gut 55(6):842–847 (June)
McFarland LV (2006) Meta-analysis of probiotics for the prevention of antibiotic associated diarrhoea and the treatment of Clostridium difficile disease. Am J Gastroenterol 101(4):812–822 (Apr)
McFarland LV, Surawicz CM, Greenberg RN, Fekety R, Elmer GW, Moyer KA et al (1994) A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. J Am Med Assoc 271(24):1913–1918 (June)
McFarland LV, Surawicz CM, Greenberg RN, Elmer GW, Moyer KA, Melcher SA et al (1995) Prevention of beta-lactam-associated diarrhoea by Saccharomyces boulardii compared with placebo. Am J Gastroenterol 90(3):439–448 (Mar)
Mearin F, Perez-Oliveras M, Perello A, Vinyet J, Ibanez A, Coderch J et al (2005) Dyspepsia and irritable bowel syndrome after a Salmonella gastroenteritis outbreak: one-year follow-up cohort study. Gastroenterology 129(1):98–104 (June)
Mimura T, Rizzello F, Helwig U, Poggioli G, Schreiber S, Talbot IC et al (2004) Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut 53(1):108–114 (Jan)
Niedzielin K, Kordecki H, Birkenfeld B (2001) A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299 V in patients with irritable bowel syndrome. Eur J Gastroenterol Hepatol 13(10):1143–1147 (Oct)
Ouwehand AC, Lagstrom H, Suomalainen T, Salminen S (2002) Effect of probiotics on constipation, faecal azoreductase activity and faecal mucin content in the elderly. Ann Nutr Metab 46(3–4):159–162.
Pare P, Ferrazzi S, Thompson WG, Irvine EJ, Rance L (2001) An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking. Am J Gastroenterol 96(11):3130–3137 (Nov)
Patterson JA, Burkholder KM (2003) Application of prebiotics and probiotics in poultry production. Poult Sci 82(4):627–631 (Apr)
Peppercorn MA (2004) The overlap of inflammatory bowel disease and diverticular disease. J Clin Gastroenterol 38(5, Suppl 1):S8–S10 (May–June)
Pillai A, Nelson R (2008) Probiotics for treatment of Clostridium difficile-associated colitis in adults. Cochrane Database Syst Rev 2008(1):CD004611
Posserud I, Stotzer PO, Bjornsson ES, Abrahamsson H, Simren M (2007) Small intestinal bacterial overgrowth in patients with irritable bowel syndrome. Gut 56(6):802–808 (June)
Prantera C, Scribano ML (2002) Probiotics and Crohn’s disease. Dig Liver Dis 34(Suppl 2):S66–S67 (Sept)
Qiao H, Duffy LC, Griffiths E, Dryja D, Leavens A, Rossman J et al (2002) Immune responses in rhesus rotavirus-challenged BALB/c mice treated with bifidobacteria and prebiotic supplements. Pediatr Res 51(6):750–755 (June)
Raza S, Graham SM, Allen SJ, Sultana S, Cuevas L, Hart CA (1995) Lactobacillus GG promotes recovery from acute nonbloody diarrhoea in Pakistan. Pediatr Infect Dis J 14(2):107–111 (Feb)
Simmering R, Blaut M (2001) Pro- and prebiotics—the tasty guardian angels? Appl Microbiol Biotechnol 55(1):19–28 (Jan)
Sonnenberg A, Koch TR (1989) Physician visits in the United States for constipation: 1958 to 1986. Dig Dis Sci 34(4):606–611 (Apr)
Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M et al (2000) Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 47(6):804–811 (Dec)
Stermer E, Lubezky A, Potasman I, Paster E, Lavy A (2006) Is traveler’s diarrhoea a significant risk factor for the development of irritable bowel syndrome? A prospective study. Clin Infect Dis 43(7):898–901 (Oct)
Stewart WF, Liberman JN, Sandler RS, Woods MS, Stemhagen A, Chee E et al (1999) Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features. Am J Gastroenterol 94(12):3530–3540 (Dec)
Szajewska H, Skorka A, Dylag M (2007a) Meta-analysis: saccharomyces boulardii for treating acute diarrhoea in children. Aliment Pharmacol Ther 25(3):257–264 (Feb)
Szajewska H, Skorka A, Ruszczyński M, Gieruszczak-Bialek D (2007b) Meta-analysis: lactobacillus GG for treating acute diarrhoea in children. Aliment Pharmacol Ther 25(8):871–881 (Apr)
Ternhag A, Torner A, Svensson A, Ekdahl K, Giesecke J (2008) Short- and long-term effects of bacterial gastrointestinal infections. Emerg Infect Dis 14(1):143–148 (Jan)
Tursi A, Brandimarte G, Giorgetti GM, Elisei W (2006) Mesalazine and/or Lactobacillus casei in preventing recurrence of symptomatic uncomplicated diverticular disease of the colon: a prospective, randomized, open-label study. J Clin Gastroenterol 40(4):312–316 (Apr)
Vanderhoof JA, Whitney DB, Antonson DL, Hanner TL, Lupo JV, Young RJ (1999) Lactobacillus GG in the prevention of antibiotic-associated diarrhoea in children. J Pediatr 135(5):564–568 (Nov)
Van Gossum A, Dewit O, Louis E, de Hertogh G, Baert F, Fontaine F et al (2007) Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn’s disease after lleo-caecal resection. Inflamm Bowel Dis 13(2):135–142 (Feb)
Van Niel CW, Feudtner C, Garrison MM, Christakis DA (2002) Lactobacillus therapy for acute infectious diarrhoea in children: a meta-analysis. Pediatrics 109(4):678–684 (Apr)
Venturi A, Gionchetti P, Rizzello F, Johansson R, Zucconi E, Brigidi P et al (1999) Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis. Aliment Pharmacol Ther 13(8):1103–1108 (Aug)
Wine E, Chan VL, Sherman PM (2008) Campylobacter jejuni mediated disruption of polarized epithelial monolayers is cell-type specific, time dependent, and correlates with bacterial invasion. Pediatr Res 64(6):599–604 (Dec)
Wine E, Gareau MG, Johnson-Henry K, Sherman PM (2009) Strain-specific probiotic (Lactobacillus helveticus) inhibition of Campylobacter jejuni invasion of human intestinal epithelial cells. FEMS Microbiol Lett 300(1):146–152 (Nov)
Wunderlich PF, Braun L, Fumagalli I, D’Apuzzo V, Heim F, Karly M et al (1989) Double-blind report on the efficacy of lactic acid-producing Enterococcus SF68 in the prevention of antibiotic-associated diarrhoea and in the treatment of acute diarrhoea. J Int Med Res 17(4):333–338 (July–Aug)
Young KT, Davis LM, Dirita VJ (2007) Campylobacter jejuni: molecular biology and pathogenesis. Nat Rev Microbiol 5(9):665–679 (Sept)
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Karimi, O., Peña, A.S. (2011). Probiotics in Clinical Practice as Therapeutics Against Enteric Disorders. In: Malago, J., Koninkx, J., Marinsek-Logar, R. (eds) Probiotic Bacteria and Enteric Infections. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0386-5_15
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