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Malignant Gliomas: Role of Platelet-Derived Growth Factor Receptor A (PDGFRA)

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Tumors of the Central Nervous System, Volume 1

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 1))

Abstract

Platelet-derived growth factor receptor A (PDGFRA), a type III receptor tyrosine kinase, is frequently up-regulated in cancer, constituting therefore an attractive pharmacological target. Several lines of evidence indicate that PDGFRA plays an important role in gliomagenesis. In the present chapter we will discuss the frequency and type of PDGFRA molecular alterations present in malignant gliomas. Furthermore, we will address the implication of such PDGFRA alterations in malignant glioma patients’ therapy response to PDGFRA targeted therapies.

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Authors and Affiliations

  1. School of Health Sciences, Life and Health Sciences Research Institute, University of Minho, 4710-056, Braga, Portugal

    Olga Martinho & Rui Manuel Reis

  2. Molecular Oncology Research Center, Barretos Cancer Hospital, CEP 14784 400, Barretos, S. Paulo, Brazil

    Rui Manuel Reis

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  1. Olga Martinho
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  2. Rui Manuel Reis
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Correspondence to Rui Manuel Reis .

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Editors and Affiliations

  1. Dept. Biological Sciences, Kean University, 1000 Moris Avenue, Union, 07083, New Jersey, USA

    M. A. Hayat

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Martinho, O., Reis, R.M. (2011). Malignant Gliomas: Role of Platelet-Derived Growth Factor Receptor A (PDGFRA). In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 1. Tumors of the Central Nervous System, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0344-5_12

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  • DOI: https://doi.org/10.1007/978-94-007-0344-5_12

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