MicroRNAs in Predicting Radiotherapy and Chemotherapy Response

  • Emily J. Noonan
  • Robert F. Place
  • Long-Cheng Li


Currently, many of the standard first line treatments for cancer consist of a combination of surgical removal, chemotherapy (CT), and radiotherapy (RT) of diseased tissue. During disease progression, tumor cells evolve and adapt to physiological states of resistance. Tumor biomarkers are proven to be useful in predicting response to CT, RT, and risk of recurrence. MicroRNAs (miRNAs) are small endogenous regulatory RNAs that are frequently dysregulated in cancer. A growing number of miRNAs are being identified in a variety of cancers with tumor suppressive and oncogenic functions. MiRNAs are also developing as a class of biomarkers that have been shown in both in vitro and in vivo studies to be useful in identifying malignant disease, classifying tumor subtypes, and as prognostic indicators. Additionally, circulating miRNAs are highly stable and detectable in tissue, urine, saliva, stool, sputum, and serum/plasma making them ideal candidates as cancer biomarkers. With these, a growing number of miRNAs have been identified as altering sensitivity to RT and CT. There is a number of previously established tumor suppressive and oncogenic miRNAs that function by regulating genes involved in cell cycle, apoptosis, multidrug resistance, and epithelial-mesenchymal transition. Use of miRNAs in predicting response to chemotherapeutics may give clinicians more accurate and/or sensitive methods to determine appropriate treatment choices.


Acute Lymphocytic Leukemia Chronic Lymphocytic Leukemia Chronic Myeloid Leukemia miRNA Expression NSCLC Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Netherlands 2011

Authors and Affiliations

  • Emily J. Noonan
    • 1
  • Robert F. Place
    • 2
  • Long-Cheng Li
    • 2
  1. 1.Department of Medicine and Department of Hematology, Center for Molecular Biology in MedicineStanford University School of Medicine, Veterans Affairs Palo Alto Health Care SystemPalo AltoUSA
  2. 2.Department of UrologyHelen Diller Comprehensive Cancer Center, University of CaliforniaSan FranciscoUSA

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