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Transient Receptor Potential Channels pp 173–183Cite as

TRPM7, the Mg2+ Inhibited Channel and Kinase

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 704)

Abstract

TRPM7 is a ubiquitously expressed nonselective cation channel fused to a C-terminal alpha kinase. TRPM7 current is typically small at physiological magnesium concentrations, but large outwardly rectifying currents develop in low-magnesium extracellular solution when cells are dialyzed with magnesium free solutions during whole-cell patch clamp recordings. In addition to regulation by magnesium, TRPM7 current is potentiated by low extracellular pH and inhibited by depletion of phosphatidylinositol 4,5-bisphosphate (PIP2) during phospholipase C mediated signaling events. A diverse body of literature has implicated TRPM7 in fundamental cellular processes including death, survival, proliferation, cell cycle progression, magnesium homeostasis and responses to shear stress and oxidative stress. Global deletion of TRPM7 in mouse results in embryonic lethality and a thymocyte-restricted conditional knockout exhibits defective thymopoeisis, suggesting a role for TRPM7 in development and organogenesis. In disease states, TRPM7 has been linked to Guamanian amyotrophic lateral sclerosis and parkinsonian dementia (ALS/PD), various forms of neoplasia, hypertension and delayed neuronal death following cerebral ischemia.

Keywords

  • Transient receptor potential
  • TRP
  • Channel-kinase
  • Magnesium
  • Calcium
  • Divalent
  • Organogenesis
  • Electrophysiology
  • PLC
  • PIP2

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Fig. 9.1
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Author information

Authors and Affiliations

  1. Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children’s Hospital Boston, 02115, Boston, MA, USA

    Chris Bates-Withers

  2. Department of Medicine, Cardiology, Brigham and Women’s Hospital, Boston, MA, 02115, USA

    Rajan Sah

  3. Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children’s Hospital Boston and Harvard University, Boston, MA, 02115, USA

    David E. Clapham

  4. Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA

    David E. Clapham

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  1. Chris Bates-Withers
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  2. Rajan Sah
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  3. David E. Clapham
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Correspondence to David E. Clapham .

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Editors and Affiliations

  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

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Bates-Withers, C., Sah, R., Clapham, D.E. (2011). TRPM7, the Mg2+ Inhibited Channel and Kinase. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_9

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