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Voltage Sensing in Thermo-TRP Channels

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Book cover Transient Receptor Potential Channels

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 704))

Abstract

Membrane voltage, ligand binding, mechanical force and temperature can all induce conformational changes that open ion channel pores. A key question in understanding ion channel function is how the protein domains involved in sensing stimuli (sensors) communicate with the pore to gate its opening and closing. TRP channels are considered six-transmembrane cation-permeable channels, distant relatives of voltage-gated potassium channels (Kv), which are known to be activated by membrane depolarization. Understanding the molecular nature of thermo-TRP channel gating offers a fair challenge to biophysicists. This chapter will summarize our present knowledge on the effect of voltage and temperature during thermo-TRP channel activation.

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Notes

  1. 1.

    Change in enzyme activity over a change of 10ºC.

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Acknowledgments

SB work is funded by FONDECYT grant 11070190. PO work is funded by FONDECYT 11090308 and DIPUV 51/2007 (U. de Valparaiso) grants. We thank Dr. H. Kurata for his critical reading of the manuscript.

Author information

Authors and Affiliations

  1. Facultad de Medicina, Instituto de Fisiologia, Universidad Austral de Chile, Valdivia, 511-0566, Chile

    Sebastian Brauchi

  2. Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile

    Patricio Orio

Authors
  1. Sebastian Brauchi
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  2. Patricio Orio
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Corresponding author

Correspondence to Sebastian Brauchi .

Editor information

Editors and Affiliations

  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

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Brauchi, S., Orio, P. (2011). Voltage Sensing in Thermo-TRP Channels. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_28

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