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Theoretical Approaches to Ribocell Modeling

  • Fabio MavelliEmail author
Chapter

Abstract

The so-called Ribocell (ribozymes-based cell) is a theoretical cellular model that has been proposed some years ago as a possible minimal cell prototype. It consists in a self-replicating minimum RNA genome coupled with a self-reproducing lipid vesicle compartment. This model assumes the existence of two hypothetical ribozymes one able to catalyze the conversion of molecular precursors into lipids and the second one able to replicate RNA strands. Therefore, in an environment rich both of lipid precursors and activated nucleotides, the ribocell can self-reproduce if the genome self-replication and the compartment self-reproduction mechanisms are somehow synchronized. The aim of this contribution is to explore the feasibility of this model with in silico simulations using kinetic parameters available in literature.

Keywords

Stochastic Simulation Deterministic Analysis Deterministic Calculation Lipid Precursor Empty Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Netherlands 2011

Authors and Affiliations

  1. 1.Chemistry DepartmentUniversity of BariBariItaly

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