β-Carotene and Other Carotenoids in Cancer Prevention

Chapter
Part of the Diet and Cancer book series (DICA, volume 2)

Abstract

Epidemiological evidence suggests associations between dietary and circulating carotenoids and reduced risk of cancer at multiple sites. However, clinical supplementation trials have returned null findings, or even evidence of harmful effects of beta-carotene supplementation in certain populations. Studies in animal models of lung cancer have provided possible mechanistic explanations for the discordance between the results of observational epidemiological studies and intervention trials using beta-carotene as a potential chemopreventive agent. As we await better scientific understanding of carotenoid metabolism and mechanisms of action, a prudent strategy to reduce the risk of cancer incidence and mortality would include increased consumption of vegetables and fruits as a part of a healthy, balanced diet.

Keywords

Carotenoids Chemoprevention 

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Department of PharmocologyUniversity of VirginaCharlottesvilleUSA
  2. 2.Nutrition and Cancer Biology LaboratoryJean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts UniversityBostonUSA
  3. 3.Nutrition and Cancer Biology LaboratoryJean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts UniversityBostonUSA

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