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Sarcopenia – Age-Related Muscle Wasting and Weakness pp 393–418Cite as

Role of IGF-1 in Age-Related Loss of Skeletal Muscle Mass and Function

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Abstract

While insulin-like growth factor-1 (IGF-1) is closely involved in the growth, hypertrophy and maintenance of skeletal muscle mass, the role of IGF-1 in age-related muscle wasting (sarcopenia) is unclear: this is the focus of the present discussion. The complexity of the IGF-1 system that involves different IGF-1 isoforms, binding proteins and receptors, with modulation of systemic IGF-1 levels by growth hormone (GH) is first outlined. The classic IGF-1 signalling pathways in skeletal muscle with a focus on the central role of Akt in protein synthesis and degradation are presented and various conditions that can impair IGF-1 signalling are discussed with respect to inflammation (TNF), oxidative stress (ROS) and lipids. Complex interactions between other factors that influence the age-related decrease in IGF-1 activity are addressed, including GH, nutrition, caloric restriction, Klotho and Vitamin D. Finally, the potential for therapeutic interventions for sarcopenia related to IGF-1 signalling is considered. The big questions are ‘to what extent does IGF-1 contribute to sarcopenia’ and ‘can elevated IGF-1 prevent or reverse sarcopenia?

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Acknowledgements

Grateful acknowledgement is made by the authors for research funding from the National Health and Medical Research Council of Australia (MG, TS), and the Foundation for Research, Science and Technology (CM). We thank Marta Fiorotto (Baylor College of Medicine, Houston, USA) for reading the manuscript and her helpful and constructive comments on the manuscript.

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  1. School of Anatomy & Human Biology, The University of Western Australia, Nedlands, WA, Australia, 6009

    Thea Shavlakadze & Miranda D. Grounds

  2. AgResearch Limited, Ruakura Research Centre, Hamilton, New Zealand

    Chris D. McMahon

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  1. Chris D. McMahon
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Correspondence to Miranda D. Grounds .

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  1. , Department of Physiology, The University of Melbourne, Melbourne, 3100, Victoria, Australia

    Gordon S. Lynch

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McMahon, C.D., Shavlakadze, T., Grounds, M.D. (2011). Role of IGF-1 in Age-Related Loss of Skeletal Muscle Mass and Function. In: Lynch, G. (eds) Sarcopenia – Age-Related Muscle Wasting and Weakness. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9713-2_17

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