Abstract
Nausea and vomiting in patients with cancer may be due to the patient’s specific disease state or may be due to cancer treatment interventions such as chemotherapy, radiation therapy, opioids, or other medications. The main approach to the treatment of nausea and vomiting has been the use of antiemetic agents developed primarily for the prevention of chemotherapy-induced nausea and vomiting (CINV). Agents that were considered useful in the prevention of CINV have then been used for the treatment of established nausea and vomiting in cancer patients. Although there have been many clinical trials in the development of agents for the prevention of CINV [62, 64, 70], there have been very few clinical trials evaluating the efficacy of antiemetics in cancer patients with established nausea and vomiting [49, 82].
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Aapro MS, Grunberg SM, Manikhas GM et al (2003) A phase III, double-blind, randomized trial of palonosetron compared with ondansetron in preventing chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy. Ann Oncol 17:1441–1449
Allison DB, Casey DE (2001) Antipsychotic-associated weight gain: A review of the literature. J Clin Psychiatr 62:22–31
Andrews PLR (1994) 5-HT3 receptor antagonists and antiemesis. In: King FD, Jones BJ, Sanger GJ (eds) s5-hydroxytryptamine-3 receptor antagonists. CRC, Boca Raton/London
Antiemetic Subcommittee of the Multinational Association of Supportive Care in Cancer (1998) Prevention of chemotherapy and radiotherapy-induced emesis: results of Perugia consensus conference. Ann Oncol 9:811–819
Arpornwirat W, Albert I, Hansen V et al (2009) Phase 2 trial results with the novel neurokini-1 receptor antagonist casopitan in combainat with ondansetron and dexamethasone for the prevention of chemotherapy-induced nausea and vomiting in cancer patients receiving moderately emetogenic chemotherapy. Cancer 115:5807–5816
Berger, AM, Clark-Snow RA (2001) Adverse effects of treatment. In: Devita VT Jr, Helman S, Rosenberg E (eds) Principles and practice of oncology. Lippincott Williams and Wilkins, PA, USA, pp 2869–2880
Borison HL, McCarthy LE (1983) Neuropharmacology of chemotherapy-induced emesis. Drugs 25:8–17
Bubalo J, Seelig F, Karbowicz S, Maziarz RT (2001) Randomized open-label trial of dolasetron for the control of nausea and vomiting associated with high-dose chemotherapy with hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 7:439–445
Bymaster FP, Calligaro D, Falcone J, Marsh RD, Moore NA, Tye NC et al (1996) Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14:87–96
Bymaster FP, Falcone JF, Bauzon D, Kennedy JS, Schenck K, DeLapp NW et al (2001) Potent antagonism of 5HT3 and 5HT6 receptors by olanzapine. Eur J Pharmacol 430:341–349
Campos D, Pereira JR, Reinhardt RR, Carracedo C, Poli S, Vogel C et al (2001) Prevention of cisplatin-induced emesis by the oral neurokinin-1 antagonist, MK-869, in combination with granisetron and dexamethasone or with dexamethasone alone. J Clin Oncol 19:1759–1767
Cartmell AD, Ferguson S, Yanagihara R, Moiseyenko V, Van Marwijk Kooy R, Tripp F et al (2003) Protection against chemotherapy-induced nausea and vomiting is maintained over multiple cycles of moderately of highly emetogenic chemotherapy by palonosetron, a potent 5HT3 receptor antagonist. In: Program/proceedings of the 39th annual meeting of the American society of clinical oncology, May 31–June 3, 2003. Chicago, IL. Abstract 3041
Chawla SP, Grunberg SM, Gralla RJ, Hesketh PJ, Rittenberg C, Elmer ME et al (2003) Establishing the dose of oral NK-1 antagonist aprepitant for chemotherapy induced nausea and vomiting. Cancer 97:2290–2300
Cocquyt V, Van Belle S, Reinhardt RR, Decramer ML, O’Brien M, Schellens JH et al (2001) Comparison of L-758,298, a prodrug for the selective neurokinin-1 antagonist L-754,030, with ondansetron for the prevention of cisplatin-induced emesis. Eur J Cancer 37:835–842
de Boer-Dennert M, de Wit R, Schmitz PI, Djontono J, Beurden V, Stoter G et al (1997) Patient perceptions of the side effects of chemotherapy: the influence of the 5-HT3 antagonists. Br J Cancer 76:1055–1061
de Witt R, Herrstedt J, Rapoport BL, Carides AD, Casrides G, Elmer M et al (2003) Addition of the oral NK1 antagonist aprepitant to standard anti-emetics provides protection against nausea and vomiting during multiple cycles of cisplatin-based chemotherapy. J Clin Oncol 21:4105–4111
de Witt R, Herrstedt J, Rapoport BL, Carides AD, Guogwang-Ma J, Elmer M et al (2004) The oral NK-1 antagonist, aprepitant, given with standard anti-emetics provides protection against nausea and vomiting over multiple cycles of cisplatin-based chemotherapy: a combined analysis of two randomized, placebo-controlled Phase III clinical trials. Eur J Cancer 40:403–410
deWit R, Schmitz PIM, Verweij J, de Boer-Dennert M, de Mulder PH, Planting AS et al (1996) Analysis of cumulative probabilities shows that the efficacy of 5-HT3 antagonist prophylaxis is not maintained. J Clin Oncol 14:644–651
Diemunsch P, Grelot L (2000) Potential of substance P antagonists as anti-emetics. Drugs 60:533–546
Einhorn LH, Brames ML, Dreicer R et al (2007) Palonosetron plus dexamethasone for the prevention of chemotherapy-induced nausea and vomiting in patients receiving multiple-day cispaltin chemotherapy for germ cell cancer. Support Care Cancer 15:1293–1300
Eisenberg P, Figueroa-Vadillo J, Zamora R, Charu V, Hajdenberg J, Cartmell A et al (2003) Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist. Results of a Phase III, single-dose trial versus dolasetron. Cancer 98:2473–2482
Eisenberg P, MacKintosh FR, Ritch P Cornett PA, Macciocchi A (2004) Efficacy, safety, and pharmacokinetics of palonosetron in patients receiving highly emetogenic, cisplatin-based chemotherapy: a dose-ranging, clinical study. Ann Oncol 15:330–337
Fabi A, Barduagni M, Lauro S, Portalone L, Mauri M, Marinis F et al (2003) Is delayed chemotherapy-induced emesis well managed in oncological clinical practice? An observational study. Support Care Cancer 11:156–161
Fabi A, Ciccaresev M, Metro G et al (2008) Oral ondansetron is highly active as rescue antiemetic treatment for moderately emetogenic chemotherapy: results of a randomized phase II study. Support Care Cancer 16:1375–1380
Fasth KJ, Bergstrom M, Kilpatrick G (1997) Brain uptake and receptor binding of two C11 labeled selective high affinity NK-1 antagonists, GR203040 and GR 205171. J Labeled Comp Radiopharm 40:665–667
Geling O, Eichler H (2005) Should 5-Hydroxytryptamine-3 receptor antagonists be administered beyond 24 hours after chemotherapy to prevent delayed emesis? Systematic re-evakluation of clinical evidence and drug cost implications. J Clin Oncol 23:1289–1294
Goldstein LE, Sporn J, Brown S, Kim H, Finkelstein J, Gaffey GK et al (1999) New-onset diabetes mellitus and diabetic ketoacidosis associated with olanzapine treatment. Psychosomatics 40:438–443
Gralla R, Lichinitser M, Van der Vegt S, Sleeboom H, Mezger J, Peschel C et al (2003) Palonosetron improves prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy: results of a double-blind randomized Phase III trial comparing single doses of palonosetron with ondansetron. Ann Oncol 14:1570–1577
Gralla RJ, Osoba D, Kris MG, Kirkbride P, Hesketh PJ, Chinnery LW et al (1999) Recommendations for the use of antiemetics: evidence-based clinical practice guidelines. J Clin Oncol 17:2971–2994
Griffin AM, Butow PN, Coates AS, Childs AM, Ellis PM, Dunn SM et al (1996) On the receiving and. V: Patient perceptions of the side effects of cancer chemotherapy in 1993. Ann Oncol 7:189–195
Grunberg SM, Deuson R, Mavros P, Geling O, Hansen M, Cruciani G et al (2004) Incidence of chemotherapy-induced nausea and emesis after modern anti-emetics: perception versus reality. Cancer 100:2261–2268
Grunberg SM, Rolski J, Strausz J et al (2009) Efficacy and safety of casoitant mesylate, a neurokinin 1 (NK-1) receptor antagonist, in prevention of chemotherapy-induced nausea and vomiting in patients receiving cisplatin-based highly emetogenic chemotherapy: a randomized, double-blind. placebo-controlled trial. Lancet Oncol 10:549–558
Guttuso T, Roscoe J, Griggs J (2003) Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer. Lancet 361:1703–1705
Hale AS (1997) Olanzapine. Br J Hosp Med 58:443–445
Herrstedt J, Apornwirat W, Shaharyar A et al (2009) Phase III of casopitant, a novel neurokinin-1 receptor antagonist, for the prevention of nausea and vomiiting in patients receiving moderately emetogenic chemotherapy. J Clin Oncol 27:5363–5369.
Hesketh PJ (2000) Comparative review of 5-HT3 receptor antagonists in the treatment of acute chemotherapy-induced nausea and vomiting. Cancer Invest 18:163–173
Hesketh PJ (2004) New treatment option for chemotherapy-induced nasusea and vomiting. Support Care Cancer 12:550–554
Hesketh PJ, Gralla RJ, Webb RT, Ueno W, DelPrete S, Bachinksy ME et al (1999) Randomized Phase II study of the neurokinin-1 receptor antagonist CJ-11,974 in the control of cisplatin-induced emesis. J Clin Oncol 17:338–343
Hesketh PJ, Grunberg SM, Gralla RJ, Warr DG, Roila F, de Wit R et al (2003) The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind placebo-controlled trial in patients receiving high-dose cisplatin-aprepitant protocol 052 study group. J Clin Oncol 21:4112–4119
Hesketh PJ, Harvey WH, Harker WG, Beck TM, Ryan T, Bricker LJ et al (1994) A randomized double blind comparison of intravenous ondansetron and in combination with intravenous dexamethasone in the prevention of high dose cisplatin induced emesis. J Clin Oncol 12:596–600
Hesketh PJ, Kris MG, Grunberg SM, Beck T, Hainsworth JD, Harker G et al (1997) Proposal for classifying the acute emetogenicity of cancer chemotherapy. J Clin Oncol 15:103–109
Hesketh PJ, Navari RM, Grote T, Gralla R, Hainsworth J, Kris M et al (1996) Double blind randomized comparison of the antiemetic efficacy of intravenous dolasetron and intravenous ondansetron in the prevention of acute cisplatin induced emesis in patients with cancer. J Clin Oncol 14:2242–2249
Hickok JT, Roscoe JA, Morrow GR et al (2005) 5-HT3 receptor antagonists versus perchlorperazine for control of delayed emesis caused by doxrubicin: a URCC CCOP randomized controlled trial. Lancet Oncol 6:756–772
Hickok JT, Roscoe JA, Morrow GR, King DK, Atkins JN, Fitch TR (2003) Nausea and emesis remain significant problems of chemotherapy despite prophylaxis with 5-hydroxytryptamine-3 anti-emetics. Cancer 97:2880–2886
Ioanmidis JP, Hesketh PJ, Lau J (2000) Contribution of dexamethasone to control of chemotherapy-induced nausea and vomiting: a meta-Analysis of randomized evidence. J Clin Oncol 18:3409–3422
Jackson WC, Tavernier L (2003) Olanzapine for intractable nausea in palliative care patients. J Palliative Med 6:251–255
Kimura E, Niimi E, Watanabe A (1996) Study on clinical effect of a continuous intravenous infusion of azasetron against the nausea and vomiting induced by anticancer drugs including CDDP. Gan To Kagaku Ryoho 23:477–481.
Kirkbride P, Bezjak A, Pater J, Zee B, Palmer MJ, Wong P et al (2000) Dexamethasone for the prophylaxis of radiation-induced Emesis: a national cancer institute of Canada clinical trials group study. J Clin Oncol 18:1960–1966
Kris MG (2003) Why do we need another anti-emetic? J Clin Oncol 21:4077–4080
Kris MG, Hesketh PJ, Somerfield MR et al (2006) American Society of clinical Oncology guidelines for antiemtics in oncology: update. J Clin Oncol 24:2932–2934
Kris MG, Pendergrass KB, Navari RM, Grote TH, Nelson AM, Thomas V et al (1997) Prevention of acute emesis following high dose cisplatin with the combination of oral dolasetron and dexamethasone. J Clin Oncol 15:2135–2138
Kris MG, Radford JE, Pizzo BA, Inabinet R, Hesketh A, Hesketh PJ (1997) Use of a NK1 receptor antagonist to prevent delayed emesis after cisplatin (letter). J Natl Cancer Inst 89:817–818
Lanciano R, Sherman DM, Michalski J. Preston AJ, Yocom K, Friedman, C (2001) The efficacy and safety of once- daily granisetron tablets in the prophylaxis of nausea and emesis following fractionated upper abdominal radiotherapy. Cancer Invest 19:763–772
Lasseter KC, Gambale J, Jin B et al (2007) Tolerability of foasaprepitant and bioequivalency to aprepitant in healthy subjects. J Clin Pharmacol 47:834–840
Latreille J, Pater J, Johnston D. Laberge F, Stewart D, Rusthoven J et al (1998) Use of dexamethasone and granisetron in the control of delayed emesis for patients who receive highly emetogenic chemotherapy. J Clin Oncol 16:1174–1178
Mantovani G, Maccio A, Alesandro B, Curreli L, Ghiani M, Proto E et al (1996) Comparison of granisetron versus ondansetron versus tropisetron in the prophylaxis of acute nausea and vomiting induced by cisplatin for the treatment of head and neck cancer; a randomized controlled trial. Cancer 77:941–948
Martin BR, Wiley JL (2004) Mechanism of action of cannabinoids; how it may lead to treatment of cachexia, emesis, and pain. J Support Oncol 2:305–316
Antiemetic Consensus Conference, Perugia, Italy (2004) Multi-national association, supportive care in cancer. Retrieved Nov 2009 from http://www.mascc.org
Minami M, Endo T, Kikuchi K, Ihira E, Hirafuji M, Hamaue N et al (1998) Antiemetic effects of sendide, a peptide tachykinin NK-1 receptor antagonist, in the ferret. Eur J Pharmacol 363:49–55
Minami M, Endo T, Yokoda H, Ogawa M, Nemoto N, Hamaue M et al (2001) Effects of CP-99,994, a tachykinin NK-1 receptor antagonist, on abdominal afferent vagal activity in ferrets: evidence for involvement of NK-1 and 5-HT3 receptors. Eur J Pharmacol 428:215–220
Morrow GR, Hickok JT, Rosenthal SN (1995) Progress in reducing nausea and emesis: comparisons of ondansetron, granisetron, and tropisetron. Cancer 76:343–357
Navari RM (2003) Pathogenesis-based treatment of chemotherapy induced nausea and vomiting: two new agents. J Support Oncol 1:89–103
Navari RM (2004) Aprepitant: a neurokinin-1 receptor antagonist for the treatment of chemotherapy-induced nausea and vomiting. Expert Rev Anticancer Ther 4(5) 715–724
Navari RM (2004) Inhibiting substance P pathway for prevention of chemotherapy-induced emesis: Preclinical data, clinical trials of neurokinin-1 receptor antagonists. Support Cancer Therapy 1:89–96
Navari RM (2007) Fosaprepitant (MK-0517): a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomting. Expert Opin Invest Drugs 16,1977–1985
Navari RM (2007) Prevention of emesis from multiple-day chemotherapy regimens. J Natl Compr Canc Netw 5:51–59
Navari RM (2007) Review of updated antiemetic guidelines for chemotherapy-nnduced nausea and vomiting. Commun Oncol 4(1 Suppl) 3S–11S
Navari RM (2008) Casopitant, a neurokinin-1 receptor antagonist with anti-emetic and antinausea activties. Curr Opin Investig Drugs 9:774–785
Navari RM (2009) Palonosetron: A second generation 5-hysroxytryptamin-3 receptor antagonist. Expert Opion Drug Metab Toxicol 5(12) 1–10
Navari RM (2009) Pharmacological management of chemotherapy-induced nausea and vomiting. Focus on recent developments. Drugs 69:515–523
Navari RM, Einhorn LH, Passik SD, Loehrer PJ, Vinson J, Johnson C et al (2005) A Phase II trial of olanzapine for the prevention of chemotherapy induced nausea and vomiting: a Hoosier oncology group study. Support Care Cancer 13:529–534
Navari RM, Einhorn LH, Passik SD, Loehrer PJ, Vinson J, Johnson C et al (2007) A Phase II trial of olanzapine, dexamethasone, and palonosetron for the prevention of chemotherapy induced nausea and vomiting: a Hoosier oncology group study. Support Care Cancer 15:1285–1291
Navari RM, Gandara D, Hesketh P, Hall S, Maillard J, Ritter H et al (1995) Comparative clinical trial of granisetron and ondansetron in the prophylaxis of cisplatin induced emesis. J Clin Oncol 13:1242–1248
Navari RM, Kaplan HG, Gralla RJ, Grunberg SM, Palmer R, Fitts D (1994) Efficacy and safety of granisetron, a selective 5-hydroxytryptamine receptor antagonist, for the prevention of nausea and vomiting induced by high dose cisplatin. J Clin Oncol 12:2204–2210
Navari RM, Koeller JM (2003) Electrocardiographic and cardiovascular effects of the 5-hydroxytryptamine-3 receptor antagonists. Ann Pharmacother 37:1276–1286
Navari RM, Madajewicz S. Anderson N, Tchekmedyian NS, Whaley W, Garewal H et al (1995) Oral ondansetron for the control of cisplatin-induced delayed emesis: a large,multicenter, double-blind, randomized comparative trial of ondansetron versus placebo. J Clin Oncol 13:2408–241
Navari RM, Reinhardt RR, Gralla RJ, Kris MG, Hesketh PJ, Khojasteh A et al (1999) Reduction of cisplatin-induced emesis by a selective neurokinin-1 receptor antagonist. N Engl J. Med 340:190–195
Clinical Practice Guidelines in Oncology: Antiemesis (2009) National comprehensive cancer network. Retrieved Nov 2009 from http://www.nccn.org
Osoba D, Zee B, Pater J, Warr D, Latreille J, Kaizer L (1997) Determinants of postchemotherapy nausea and vomiting in patients with cancer. J Clin Oncol 15:116–123
Osoba D, Zee B, Warr D, Latreille J, Kaizer L, Pater J (1997) Effect of post-chemotherapy nausea and vomiting on health related quality of life. Support Care Cancer 5:307–313
Passik SD, Kirsh KL, Theobald DE, Dickerson P, Trowbridge R, Gray D et al (2003) A retrospective chart review of the use of olanzapine for the prevention of delayed emesis in cancer patients. J Pain Symptom Manage 25:485–489
Passik SD, Lundberg J, Kirsh K, Theobald D, Donaghy K, Holtsclaw E et al (2002) A pilot exploration of the antiemetic activity of olanzapine (Zyprexa) for the relief of nausea in patients with advanced cancer and pain. J Pain and Symptom Manage 23:526–532
Passik SD, Navari RM, Jung S, Nagy C, Vinson J, Kirsh K et al (2004) A phase I trail of olanzapine (Zyprexa) for the prevention of delayed emesis in cancer patients receiving chemotherapy. Cancer Invest 22:383–388
Perez EA (1999) 5-HT3 antiemetic therapy for patients with breast cancer. Breast Cancer Res Treat 57:207–214
Perez EA (1995) Review of the preclinical pharmacology and comparative efficacy of 5-hydroxytryptamine-3 receptor antagonists for chemotherapy-induced emesis. J Clin Oncol 13:1036–1043
Perez EA, Navari RM, Kaplan HG, Gralla RJ, Grunberg SM, Palmer RH et al (1997) Efficacy and safety of different doses of granisetron for the prophylaxis of cisplatin induced emesis. Support Care Cancer 5:31–37
Pirl WF, Roth AJ (2000) Remission of chemotherapy-induced emesis with concurrent olanzapine treatment: a case report. Psychooncology 9:84–87
Poli-Bigelli S, Rodrigues-Pereira J, Carides AD, Julie Ma G, Eldridge K, Hipple A et al (2003) Addition of the neurokinin-1 receptor antagonist aprepitant to standard anti-emetic therapy improves control of chemotherapy-induced nausea and vomiting. Cancer 97:3090–3098
Roila F, Hesketh PJ, Herrstedt J (2006) Antiemetic subcommittee of the multinational association of supportive care in cancer. Ann Oncol 17:22–28
Rudd JA, Naylor RJ (1994) Effects of 5-HT3 receptor antagonists on models of acute and delayed emesis induced by cisplatin in the ferret. Neuropharmacology 33:1607–1608
Saito M, Aogi K, Sekine I et al (2009) Palonosetron plus dexamethasoneversus granisetron plus dexamethasone for the prevention of nausea and vomiting during chemotherapy: a double-blind, double dummy, randomized comparative phase III trial. Lancer Oncol 10:115–124
Sanger GJ (1992) The involvement of the 5-HT3 receptors in visceral function. In: Harmon M (ed) Central and peripheral 5-HT3 Receptors (pp. 207–255). Academic, London
Schmoll HJ, Aapro MS, Poli-Bigelli S et al (2006) Comparison of an aprepitant regimen with a multi-day ondansetron regimen, both with dexamethasone, for the antiemetic efficacy in high-dose cisplatin treatment. Ann Oncol 17(6):1000–1006
Simpson K, Spencer CM, McClellan KJ (2000) Topisetron: an update of its use in the prevention of chemotherapy-induced nausea and vomiting. Drugs 59:1297–1315
Slatin MD (2007) Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting beyond prevention of acute emesis. J Support Oncol 5(3 Suppl): 1S–9S
Srivastava M, Brito-Dellan N, Davis MP, Leach M, Lagman R (2003) Olanzapine as an antiemetic in refractory nausea and vomiting in advanced cancer. J. Pain Symptom Manage 25:578–582
Taguchi T, Tsukamoto F, Watanabe T (1999) Usefulness of ramosetron hydrochloride on nausea and vomting in CMF or CEF therapy for breast cancer. Gan To Kagaku Ryoho 26:1163–1170
Tattersall FD, Rycroft W, Cumberbatch M, Mason G, Tye S, Williamson DJ et al (2000) The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phsophoryl prodrug, L-758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets. Neuropharmacology 39:652–663
Tattersall FD, Rycroft W, Francis B, Pearce D, Merchant K, MacLeod AM et al (1996) Tachykinins NK-1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology 35:1121–1129
Tavorath FD, Hesketh PJ (1996) Drug treatment of chemotherapy-induced delayed emesis. Drugs 52: 639–648
The Italian Group for Anti-emetic Research (2000) Dexamethasone alone or in combination with ondansetron for the prevention of delayed nausea and vomiting induced by chemotherapy. N Engl J Med 342:1554–1559
The Italian Group for Anti-emetic Research (1995) Dexamethasone, granisetron, or both for the prevention of nausea and vomiting during chemotherapy for cancer. N Engl J Med 332:1–5
The Italian Group for Anti-emetic Research (1998) Double blind dose finding study of four intravenous doses of dexamethasone in the prevention of cisplatin induced acute emesis. N Engl J Med 16:2937–2942
The Italian Group for Anti-emetic Research (2004) Randomized, double-blind, dose-finding study of dexamethasone in preventing acute emesis induced by anthrcyclines, carboplatin, or cyclophosphamide (published erratum appears in J Clin Oncol 22:2038). J Clin Oncol 22:725–729
Van Belle S, Liechinitser M, Navari RM, Garin AM, Decramer ML, Riviere A et al (2002) Prevention of cisplatin-induced acute and delayed emesis by the selective neurokinin-1 antagonists, L-758,298 and MK-0869. Cancer 94:3032–3041
Van Sickle MD, Duncan M, Kingsley PJ et al (2005) Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science 310:329–332
Warr DG, Hesketh PJ, Gralla RJ et al (2005) Efficacy and tolerability of aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with breast cancer after moderately emetogenic chemotherapy. J Clin Oncol 23:2822–2830
Yates BJ, Grelot L, Kerman IA, Balaban CD, Jakus J, Miller AD (1994) Organization of the vestibular inputs to nucleus tractus solitarius and adjacent structures in cat brain stem. Am J Physiol 207–255
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media B.V.
About this chapter
Cite this chapter
Navari, R.M., Province, P.P., Passik, S.D. (2011). Management of Nausea and Vomiting in Cancer Patients. In: Minev, B. (eds) Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures. Cancer Growth and Progression, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9704-0_25
Download citation
DOI: https://doi.org/10.1007/978-90-481-9704-0_25
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-9703-3
Online ISBN: 978-90-481-9704-0
eBook Packages: MedicineMedicine (R0)