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Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures pp 365–377Cite as

Induced Hyperthermia in the Treatment of Cancer

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Part of the book series: Cancer Growth and Progression ((CAGP,volume 13))

Abstract

The term “hyperthermia” summarizes the treatment of malignant diseases by application of heat by using different techniques. Hyperthermia is usually applied as an adjunct to an established treatment modality claiming intratumoral temperatures in the range of 40–43°C. Several clinical phase-III trials have demonstrated improvements in clinical outcome when locoregional hyperthermia is added to radio- and/or chemotherapy in patients with locally advanced or recurrent superficial and pelvic tumors. Further studies revealed a benefit for hyperthermic chemoperfusion as adjuvant therapy in patients with abdominal malignancies or malignant melanoma of the extremities. Finally, the addition of whole-body hyperthermia to systemic chemotherapy has revealed promising results in a number of recent phase – II studies. This chapter gives a summary on the recent results in clinical hyperthermia research, and points out the most interesting future developments.

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References

  1. Eggermont AM, Brunstein F, Grunhagen D, ten Hagen TL (2004) Regional treatment of metastasis: role of regional perfusion. State of the art isolated limb perfusion for limb salvage. Ann Oncol 15(Suppl 4):iv107–iv112

    PubMed  Google Scholar 

  2. Hildebrandt B, Hegewisch-Becker S, Kerner T, Nierhaus A, Bakhshandeh-Bath A, Janni W et al (2005) Current status of radiant whole-body hyperthermia at temperatures > 41.5°C and practical guidelines for the treatment of adults. The German “interdisciplinary working group on hyperthermia”. Int J Hyperthermia 21(2):169–183

    Article  CAS  PubMed  Google Scholar 

  3. Stewart JHT, Shen P, Levine EA (2005) Intraperitoneal hyperthermic chemotherapy for peritoneal surface malignancy: current status and future directions. Ann Surg Oncol 12(10):765–777

    Article  PubMed  Google Scholar 

  4. Wust P, Hildebrandt B, Sreenivasa G, Rau B, Gellermann J, Riess H et al (2002) Hyperthermia in combined treatment of cancer. Lancet Oncol 3(8):487–497

    Article  CAS  PubMed  Google Scholar 

  5. van Der Zee J (2002) Heating the patient: a promising approach? Ann Oncol 13(8):1173–1184

    Article  PubMed  Google Scholar 

  6. Diederich CJ (2005) Thermal ablation and high-temperature thermal therapy: overview of technology and clinical implementation. Int J Hyperthermia 21(8):745–753

    Article  PubMed  Google Scholar 

  7. Hildebrandt B, Wust P, Ahlers O, Dieing A, Sreenivasa G, Kerner T et al (2002) The cellular and molecular basis of hyperthermia. Crit Rev Oncol Hematol 43(1):33–56

    Article  PubMed  Google Scholar 

  8. Sapareto SA, Dewey WC (1984) Thermal dose determination in cancer therapy. Int J Radiat Oncol Biol Phys 10(6):787–800

    Article  CAS  PubMed  Google Scholar 

  9. Jones EL, Prosnitz LR, Dewhirst MW, Vujaskovic Z, Samulski TV, Oleson JR et al (2005) In regard to Vasanathan et al (Int J Radiat Oncol Biol Phys 2005;61:145–153). Int J Radiat Oncol Biol Phys 63(2):644

    PubMed  Google Scholar 

  10. van der Zee J, van Rhoon GC, Wust P (2005) In regard to Dr. Vasanthan et al (Int J Radiat Oncol Biol Phys 2005;61:145–153). Int J Radiat Oncol Biol Phys 62(3):940–941

    Article  PubMed  Google Scholar 

  11. Vasanthan A, Mitsumori M, Park JH, Zhi-Fan Z, Yu-Bin Z, Oliynychenko P et al (2005) Regional hyperthermia combined with radiotherapy for uterine cervical cancers: a multi-institutional prospective randomized trial of the international atomic energy agency. Int J Radiat Oncol Biol Phys 61(1):145–153

    Article  PubMed  Google Scholar 

  12. Yonemura Y, de Aretxabala X, Fujimura T, Fushida S, Katayama K, Bandou E et al (2001) Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: final results of a randomized controlled study. Hepatogastroenterology 48(42):1776–1782

    CAS  PubMed  Google Scholar 

  13. Wust P, Riess H, Hildebrandt B, Loffel J, Deja M, Ahlers O et al (2000) Utilizing the Iratherm-2000 infrared system for whole-body hyperthermia at 42°C – a feasibility study. Int J Hyperthermia 16(4):325–339

    Article  CAS  PubMed  Google Scholar 

  14. Sugarbaker PH (2006) New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome? Lancet Oncol 7(1):69–76

    Article  PubMed  Google Scholar 

  15. Lagendijk JJ, Van Rhoon GC, Hornsleth SN, Wust P, De Leeuw AC, Schneider CJ et al (1998) ESHO quality assurance guidelines for regional hyperthermia. Int J Hyperthermia 14(2):125–133

    Article  CAS  PubMed  Google Scholar 

  16. Wust P, Fähling H, Felix R, Rahman S, Issels R, Feldmann HJ et al (1995) Quality control of the SIGMA applicator using a lamp phantom: a 4-center comparison. Int J Hyperthermia 11:755–767

    Article  CAS  PubMed  Google Scholar 

  17. Hildebrandt B, Rau B, Gellermann J, Kerner T, Nicolaou A, Blohmer JU et al (2004) Standards and perspectives in locoregional hyperthermia. Wien Med Wochenschr 154(7–8):148–158

    Article  PubMed  Google Scholar 

  18. Kroeze H, van de Kamer JB, de Leeuw AA, Kikuchi M, Lagendijk JJ (2003) Treatment planning for capacitive regional hyperthermia. Int J Hyperthermia 19(1):58–73

    Article  CAS  PubMed  Google Scholar 

  19. Verwaal VJ, van Ruth S, de Bree E, van Sloothen GW, van Tinteren H, Boot H et al (2003) Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. J Clin Oncol 21(20):3737–3743

    Article  PubMed  Google Scholar 

  20. Overgaard J (1989) The current and potential role of hyperthermia in radiotherapy. Int J Radiat Oncol Biol Phys 16(3):535–549

    Article  CAS  PubMed  Google Scholar 

  21. van der Zee J, Treurniet-Donker AD, The SK, Helle PA, Seldenrath JJ, Meerwaldt JH et al (1988) Low dose reirradiation in combination with hyperthermia: a palliative treatment for patients with breast cancer recurring in previously irradiated areas. Int J Radiat Oncol Biol Phys 15(6):1407–1413

    Article  PubMed  Google Scholar 

  22. Emami B, Scott C, Perez CA, Asbell S, Swift P, Gringsby P et al (1996) Phase III study of interstitial thermoradiotherapy compared with interstitial radiotherapy alone in the treatment of recurrent or persistant human tumors. A prospectively controlled randomized study by the radiation therapy group. Int J Radiat Oncol Biol Phys 34(5):1097–1104

    Article  CAS  PubMed  Google Scholar 

  23. Jones EL, Oleson JR, Prosnitz LR, Samulski TV, Vujaskovic Z, Yu D et al (2005) Randomized trial of hyperthermia and radiation for superficial tumors. J Clin Oncol 23(13):3079–3085

    Article  PubMed  Google Scholar 

  24. Overgaard J, Gonzalez Gonzalez D, Huslhof MCCH et al (1996) Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicentre randomized trial by the European society for hyperthermic oncolgy. Int J Hyperthermia 12:3–20

    Article  CAS  PubMed  Google Scholar 

  25. Perez CA, Pajak T, Emami B, Hornback NB, Tupchong L, Rubin P (1991) Randomized phase III study comparing irradiation and hyperthermia with irradiation alone in superficial measurable tumors. Final report by the radiation therapy oncology group. Am J Clin Oncol 14(2):133–141

    Article  CAS  PubMed  Google Scholar 

  26. Valdagni R, Amichetti M (1993) Report of a long-term follow-up in a randomized trial comparing radiation therapy and radiation plus hyperthermia to metastatic lymph nodes in stage IV head and neck cancer patients. Int J Radiat Oncol 28:163–169

    Google Scholar 

  27. Vernon C, Hand JW, Field SB et al (1996) Radiotherapy with or without hypethermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. Int J Radiat Oncol Biol Phys 35:731–744

    Article  CAS  PubMed  Google Scholar 

  28. Sneed PK, Stauffer PR, McDermott MW et al (1998) Survival benefit of hyperthermia in a prospective randomised trial of brachytherapy boost +/– hyperthermia for glioblastoma multiforme. Int J Radiat Oncol Biol Phys 40:287–295

    Article  CAS  PubMed  Google Scholar 

  29. Engin K, Tupchong L, Moylan DJ, Alexander GA, Waterman FM, Komarnicky L et al (1993) Radomized trial of one versus two adjuvant hyperthermia treatments per week in patients with superficial tumors. Int J Hyperthermia 9(3):327–340

    Article  CAS  PubMed  Google Scholar 

  30. Kapp DS, Petersen IA, Cox RS, Hahn GM, Fessenden P, Prionas SD et al (1990) Two or six hyperthermia treastments as an adjunct to radiation therapy yield similar tumor resonses: results of a randomized trial. Int J Radiat Oncol Biol Phys 19:1481–1495

    Article  CAS  PubMed  Google Scholar 

  31. Oleson JR, Samulski TV, Leopold KA, Clegg ST, Dewhirst MW, Dodge RK et al (1993) Sensitivity of hyperthermia trial outcomes to temperature and time: implications for thermal goals of treatment. Int J Radiat Oncol Bio Phys 25(2):289–297

    Article  CAS  Google Scholar 

  32. Hand JW, Machin D, Vernon CC, Whaley JB (1997) Analysis of thermal parameters obtained during phase III trials of hyperthermia as an adjunct to radiotherapy in the treatment of breast carcinoma. Int J Hyperthermia 13(4):343–364

    Article  CAS  PubMed  Google Scholar 

  33. Wust P, Beck R, Berger J, Fahling H, Seebass M, Wlodarczyk W et al (2000) Electric field distributions in a phased-array applicator with 12 channels: measurements and numerical simulations. Med Phys 27(11):2565–2579

    Article  CAS  PubMed  Google Scholar 

  34. Gellermann J, Wust P, Stalling D, Seebass M, Nadobny J, Beck R et al (2000) Clinical evaluation and verification of the hyperthermia treatment planning system hyperplan. Int J Radiat Oncol Biol Phys 47(4):1145–1156

    Article  CAS  PubMed  Google Scholar 

  35. Seebass M, Beck R, Gellermann J, Nadobny J, Wust P (2001) Electromagnetic phased arrays for regional hyperthermia: optimal frequency and antenna arrangement. Int J Hyperthermia 17(4):321–336

    Article  CAS  PubMed  Google Scholar 

  36. Kroeze H, Van Vulpen M, De Leeuw AA, Van de Kamer JB, Lagendijk JJ (2001) The use of absorbing structures during regional hyperthermia treatment. Int J Hyperthermia 17(3):240–257

    Article  CAS  PubMed  Google Scholar 

  37. Sreenivasa G, Gellermann J, Rau B, Nadobny J, Schlag P, Deuflhard P et al (2003) Clinical use of the hyperthermia treatment planning system HyperPlan to predict effectiveness and toxicity. Int J Radiat Oncol Biol Phys 55(2):407–419

    Article  PubMed  Google Scholar 

  38. Dinges S, Harder C, Wurm R, Buchali A, Blohmer J, Gellermann J et al (1998) Combined treatment of inoperable carcinomas of the uterine cervix with radiotherapy and regional hyperthermia. Results of a phase II trial. Strahlenther Onkol 174(10):517–521

    Article  CAS  PubMed  Google Scholar 

  39. Issels R, Prenninger SW, Nagele A, Boehm E, Sauer H, Jauch K-W et al (1990) Ifosfamide plus etoposide combined with regional hyperthermia in patients with locally advanced sarcomas. J Clin Oncol 11:1818–1829

    Google Scholar 

  40. Rau B, Wust P, Tilly W, Gellermann J, Harder C, Riess H et al (2000) Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters. Int J Radiat Oncol Biol Phys 48(2):381–391

    Article  CAS  PubMed  Google Scholar 

  41. Tilly W, Wust P, Rau B, Harder C, Gellermann J, Schlag P et al (2001) Temperature data and specific absorption rates in pelvic tumors: predicitve factors and correlations. Int J Hyperthermia 17(2):172–188

    Article  CAS  PubMed  Google Scholar 

  42. Wust P, Stahl H, Dieckmann K, Scheller S, Löffel J, Riess H et al (1996) Local hypert-hermia of N2/N3 cervical lymphnode metastases: correlation of technical/ thermal parameters and response. Int J Radiat Oncol Biol Phys 34:635–646

    Article  CAS  PubMed  Google Scholar 

  43. van der Zee J, Gonzalez Gonzalez D, van Rhoon GC, van Dijk JD, van Putten WL, Hart AA (2000) Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch deep hyperthermia group. Lancet 355(9210):1119–1125

    Article  PubMed  Google Scholar 

  44. Dahl O, Mella O (2002) Referee: hyperthermia alone or combined with cisplatin in addition to radiotherapy for advanced uterine cervical cancer. Int J Hyperthermia 18(1):25–30

    Article  CAS  PubMed  Google Scholar 

  45. Hildebrandt B, Wust P, Rau B, Schlag PM, Riess H (2000) Regional hyperthermia in rectal cancer. Lancet 356(9231):771–772

    Article  CAS  PubMed  Google Scholar 

  46. Prosnitz L (2002) A new phase III trial for treatment of carcinoma of the cervix. Int J Hyperthermia 18(1):31–32

    Article  CAS  PubMed  Google Scholar 

  47. Prosnitz L, Jones E (2002) Counterpoint: test the value of hyperthermia in patients with carcinoma of the cervix being treated with concurrent chemotherapy and radiation. Int J Hyperthermia 18(1):13–18

    Article  CAS  PubMed  Google Scholar 

  48. van der Zee J, Gonzalez GD (2002) The Dutch Deep Hyperthermia Trial: results in cervical cancer. Int J Hyperthermia 18(1):1–12

    Article  PubMed  Google Scholar 

  49. van der Zee J, Koper PC, Lutgens LC, Burger CW (2002) Point-counterpoint: what is the optimal trial design to test hyperthermia for carcinoma of the cervix? Point: addition of hyperthermia or cisplatin to radiotherapy for patients with cervical cancer; two promising combinations – no definite conclusions. Int J Hyperthermia 18(1):19–24

    Article  PubMed  Google Scholar 

  50. Westermann AM, Jones EL, Schem BC, van der Steen-Banasik EM, Koper P, Mella O et al (2005) First results of triple-modality treatment combining radiotherapy, chemotherapy, and hyperthermia for the treatment of patients with stage IIB, III, and IVA cervical carcinoma. Cancer 104(4):763–770

    Article  CAS  PubMed  Google Scholar 

  51. Rau B, Wust P, Hohenberger P, Loffel J, Hunerbein M, Below C et al (1998) Preoperative hyperthermia combined with radiochemotherapy in locally advanced rectal cancer: a phase II clinical trial. Ann Surg 227(3):380–389

    Article  CAS  PubMed  Google Scholar 

  52. Riess H, Loffel J, Wust P, Rau B, Gremmler M, Speidel A et al (1995) A pilot study of a new therapeutic approach in the treatment of locally advanced stages of rectal cancer: neoadjuvant radiation, chemotherapy and regional hyperthermia. Eur J Cancer 31A:1356–1360

    Article  CAS  PubMed  Google Scholar 

  53. Wendtner CM, Abdel-Rahman S, Krych M, Baumert J, Lindner LH, Baur A et al (2002) Response to neoadjuvant chemotherapy combined with regional hyperthermia predicts long-term survival for adult patients with retroperitoneal and visceral high-risk soft tissue sarcomas. J Clin Oncol 20(14):3156–3164

    Article  CAS  PubMed  Google Scholar 

  54. Berdov BA, Menteshashvili GZ (1990) Thermoradiotherapy of patients with locally advanced carcinoma of the rectum. Int J Hyperthermia 6(5):881–890

    Article  CAS  PubMed  Google Scholar 

  55. Datta NR, Bose AK, Kapoor HK (1987) Thermoradiotherapy in the management of carcinoma of the cervix (stage IIIb): a controlled clinical study. Indian Med Gazette 121:68–71

    Google Scholar 

  56. Datta NR, Bose AK, Kapoor HK, Gupta S (1990) Head and neck cancers: results of thermoradiotherapy versus radiotherapy. Int J Hyperthermia 6(3):479–486

    Article  CAS  PubMed  Google Scholar 

  57. Harima Y, Nagata K, Harinma K, Ostapenko VV, Tanaka Y, Sawada S (2001) A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage III cervical carcinoma. Int J Hyperthermia 17(2):97–105

    Article  CAS  PubMed  Google Scholar 

  58. Kitamura K, Kuwano H, Watanabe M, Nozoe T, Yasuda M, Sumiyoshi K et al (1995) Prospective randomized study of hyperthermia combines with chemoradiotherapy for esophageal carcinoma. J Surg Oncol 60:55–58

    Article  CAS  PubMed  Google Scholar 

  59. Sharma S, Patel FD, Sandhu APS, Gupta BD, Yadav NS (1989) A prospective ramdomised study of local hyperthermia as a supplement to and radiosensitiser in the treatment of carcinoma of the cervix with radiotherapy. Endocurietherapy/Hypertherm Oncol 5:151–159

    Google Scholar 

  60. Sugimachi K, Kuwano H, Ide T, Toge T, Saku M, Oshiumi Y (1994) Chemotherapy combined with or without hyperthermia for patients with oesophageal carcinoma: a prospective randomized trial. Int J Hyperthermia 10(4):485–493

    Article  CAS  PubMed  Google Scholar 

  61. Eggermont AM, de Wilt JH, ten Hagen TL (2003) Current uses of isolated limb perfusion in the clinic and a model system for new strategies. Lancet Oncol 4(7):429–437

    Article  PubMed  Google Scholar 

  62. Ghussen F, Krüger I, Smalley R, Groth W (1989) Hyperthermic perfusion with chemotherapy for melanoma of the extremeties. World J Surg 13:598–602

    Article  CAS  PubMed  Google Scholar 

  63. Koops HS, Vaglini M, Suciu S, Kroon BBR, Thompson JF, Göhl J et al (1998) Prophylactic isolated limb perfusion for localized, high-risk limb melanomas: results of a multicenter randomized phase III trial. J Clin Oncol 16:2906–2912

    CAS  PubMed  Google Scholar 

  64. Jost LM, Jelic S, Purkalne G (2005) ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of cutaneous malignant melanoma. Ann Oncol 16(Suppl 1):i66–i68

    Article  PubMed  Google Scholar 

  65. Leyvraz S, Jelic S (2005) ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of soft tissue sarcomas. Ann Oncol 16(Suppl 1):i69–i70

    Article  PubMed  Google Scholar 

  66. Grover A, Alexander HR Jr (2004) The past decade of experience with isolated hepatic perfusion. Oncologist 9(6):653–664

    Article  PubMed  Google Scholar 

  67. Rothbarth J, Tollenaar RA, Schellens JH, Nortier JW, Kool LJ, Kuppen PJ et al (2004) Isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: recent trends and perspectives. Eur J Cancer 40(12):1812–1824

    Article  CAS  PubMed  Google Scholar 

  68. Van Putte BP, Hendriks JM, Romijn S, Van Schil PE (2003) Isolated lung perfusion for the treatment of pulmonary metastases current mini-review of work in progress. Surg Oncol 12(3):187–193

    Article  PubMed  Google Scholar 

  69. Sugarbaker PH (2004) Managing the peritoneal surface component of gastrointestinal cancer. Part 2. Perioperative intraperitoneal chemotherapy. Oncology (Williston Park) 18(2):207–219; discussion 220–222, 227–228, 230

    Google Scholar 

  70. Silberman H (2005) Perioperative adjunctive treatment in the management of operable gastric cancer. J Surg Oncol 90(3):174–186; discussion 186–187

    Article  PubMed  Google Scholar 

  71. Fujimoto S, Takahashi M, Mutou T, Kobayashi K, Toyosawa T (1999) Successful intraperitoneal hyperthermic chemoperfusion for the prevention of postoperative peritoneal recurrence in patients with advanced gastric carcinoma. Cancer 85(3):529–534

    Article  CAS  PubMed  Google Scholar 

  72. Hamazoe R, Maeta M, Kaibara N (1994) Intraperitoneal thermochemotherapy for prevention of peritoneal recurrence of gastric cancer. Cancer 73:2048–2052

    Article  CAS  PubMed  Google Scholar 

  73. Kim JY, Bae HS (2001) A controlled clinical study of serosa-invasive gastric carcinoma patients who underwent surgery plus intraperitoneal hyperthermo-chemo-perfusion (IHCP). Gastric Cancer 4(1):27–33

    Article  CAS  PubMed  Google Scholar 

  74. Yu W, Whang I, Chung HY, Averbach A, Sugarbaker PH (2001) Indications for early postoperative intraperitoneal chemotherapy of advanced gastric cancer: results of a prospective randomized trial. World J Surg 25(8):985–990

    Article  CAS  PubMed  Google Scholar 

  75. Rosen HR, Jatzko G, Repse S, Potrc S, Neudorfer H, Sandbichler P et al (1998) Adjuvant intraperitoneal chemotherapy with carbon-adsorbed mitomycin in patients with gastric cancer: results of a randomized multicenter trial of the Austrian working group for surgical oncology. J Clin Oncol 16(8):2733–2738

    CAS  PubMed  Google Scholar 

  76. Sautner T, Hofbauer F, Depisch D, Schiessel R, Jakesz R (1994) Adjuvant intraperitoneal cisplatin chemotherapy does not improve long-term survival after surgery for advanced gastric cancer. J Clin Oncol 12(5):970–974

    CAS  PubMed  Google Scholar 

  77. Hildebrandt B, Rau B, Gellermann J, Wust P, Riess H (2004) Hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinosis. J Clin Oncol 22(8):1527–1529

    Article  PubMed  Google Scholar 

  78. Nadobny J, Wlodarczyk W, Westhoff L, Gellermann J, Felix R, Wust P (2005) A clinical water-coated antenna applicator for MR-controlled deep-body hyperthermia: a comparison of calculated and measured 3-D temperature data sets. IEEE Trans Biomed Eng 52(3):505–519

    Article  PubMed  Google Scholar 

  79. Nadobny J, Wlodarczyk W, Westhoff L, Gellermann J, Rau B, Monich G et al (2003) Development and evaluation of a three-dimensional hyperthermia applicator with Water-Coated Antennas (WACOA). Med Phys 30(8):2052–2064

    Article  PubMed  Google Scholar 

  80. Gellermann J, Wlodarczyk W, Feussner A, Fahling H, Nadobny J, Hildebrandt B et al (2005) Methods and potentials of magnetic resonance imaging for monitoring radiofrequency hyperthermia in a hybrid system. Int J Hyperthermia 21(6):497–513

    Article  CAS  PubMed  Google Scholar 

  81. Gellermann J, Wlodarczyk W, Hildebrandt B, Ganter H, Nicolau A, Rau B et al (2005) Noninvasive magnetic resonance thermography of recurrent rectal carcinoma in a 1.5 Tesla hybrid system. Cancer Res 65(13):5872–5880

    Article  CAS  PubMed  Google Scholar 

  82. Wust P, Gellermann J, Seebass M, Fahling H, Turner P, Wlodarczyk W et al (2004) Part-body hyperthermia with a radiofrequency multiantenna applicator under online control in a 1.5 T MR-tomograph. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 176(3):363–374

    Article  CAS  PubMed  Google Scholar 

  83. Jordan A, Wust P, Fahling H, John W, Hinz A, Felix R (1993) Inductive heating of ferromagnetic particles and magnetic fluids: physical evaluation of their potential for hyperthermia. Int J Hyperthermia 1993(9):51–68

    Article  Google Scholar 

  84. Moroz P, Jones SK, Gray BN (2002) Magnetically mediated hyperthermia: current status and future directions. Int J Hyperthermia 18(4):267–284

    Article  CAS  PubMed  Google Scholar 

  85. Johannsen M, Gneveckow U, Eckelt L, Feussner A, Waldofner N, Scholz R et al (2005) Clinical hyperthermia of prostate cancer using magnetic nanoparticles: presentation of a new interstitial technique. Int J Hyperthermia 21(7):637–647

    Article  CAS  PubMed  Google Scholar 

  86. Johannsen M, Thiesen B, Gneveckow U, Taymoorian K, Waldofner N, Scholz R et al (2006) Thermotherapy using magnetic nanoparticles combined with external radiation in an orthotopic rat model of prostate cancer. Prostate 66(1):97–104

    Article  CAS  PubMed  Google Scholar 

  87. Kong G, Dewhirst MW (1999) Hyperthermia and liposomes. Int J Hyperthermia 15(5):345–370

    Article  CAS  PubMed  Google Scholar 

  88. Lindner LH, Issels R (2003) Thermosensitive liposomes for regional hyperthermia. German. Dt Med Wschr 128:2020–2022

    Article  CAS  Google Scholar 

  89. Hettinga JV, Konings AW, Kampinga HH (1997) Reduction of cellular cisplatin resistance by hyperthermia – a review. Int J Hyperthermia 13(5):439–457

    Article  CAS  PubMed  Google Scholar 

  90. Vanakoski J, Seppälä T (1998) Heat exposure and drugs. Clin Pharmacokinet 34(4):311–322

    Article  CAS  PubMed  Google Scholar 

  91. Harris M (2004) Monoclonal antibodies as therapeutic agents for cancer. Lancet Oncol 5(5):292–302

    Article  CAS  PubMed  Google Scholar 

  92. Hauck ML, Zalutsky MR (2005) Enhanced tumour uptake of radiolabelled antibodies by hyperthermia. Part II: application of the thermal equivalency equation. Int J Hyperthermia 21(1):13–27

    Article  CAS  PubMed  Google Scholar 

  93. Hauck ML, Zalutsky MR (2005) Enhanced tumour uptake of radiolabelled antibodies by hyperthermia: part I: timing of injection relative to hyperthermia. Int J Hyperthermia 21(1):1–11

    Article  CAS  PubMed  Google Scholar 

  94. Kinuya S, Yokoyama K, Michigishi T, Tonami N (2004) Optimization of radioimmunotherapy interactions with hyperthermia. Int J Hyperthermia 20(2):190–200

    Article  CAS  PubMed  Google Scholar 

  95. Brade AM, Szmitko P, Ngo D, Liu FF, Klamut HJ (2003) Heat-directed suicide gene therapy for breast cancer. Cancer Gene Ther 10(4):294–301

    Article  CAS  PubMed  Google Scholar 

  96. Li CY, Dewhirst MW (2002) Hyperthermia-regulated immunogene therapy. Int J Hyperthermia 18(6):586–596

    Article  CAS  PubMed  Google Scholar 

  97. Huang Q, Hu JK, Lohr F, Zhang L, Braun R, Lanzen J et al (2000) Heat-induced gene expression as a novel targeted cancer gene therapy strategy. Cancer Res 60(13):3435–3439

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Medizinische Klinik für Hämatologie und Onkologie, Charité Universitätsmedizin Berlin, Humboldt-Universität, Campus Virchow Klinikum, D-13344, Berlin, Germany

    Bert Hildebrandt & Hanno Riess

  2. Klinik für Strahlenheilkunde, Charité Universitätsmedizin Berlin, Humboldt-Universität, Campus Virchow Klinikum, D-13344, Berlin, Germany

    Johanna Gellermann & Peter Wust

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  1. Bert Hildebrandt
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Correspondence to Bert Hildebrandt .

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  1. Moores UCSD Cancer Center, 3855 Health Sciences Drive 0820, La Jolla, 92093-0820, California, USA

    Boris R. Minev

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Hildebrandt, B., Gellermann, J., Riess, H., Wust, P. (2011). Induced Hyperthermia in the Treatment of Cancer. In: Minev, B. (eds) Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures. Cancer Growth and Progression, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9704-0_21

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