Pathoadaptation of Especially Dangerous Pathogens

  • Alexander Rakin
Conference paper
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA, volume 00)


Gene acquisition by lateral gene transfer is considered to play the main role in the evolution of bacteria, including those that are especially dangerous. However, gene gain alone cannot explain the high virulence potential of especially dangerous pathogens. Negative selection (pathoadaptive mutations) plays an important role in pathogens’ evolution. Moreover, point mutations might drastically change the mode of behavior of the pathogen or its host range. All of these mechanisms must be taken into account to understand the emergence and peculiarities of especially dangerous pathogens.


Horizontal Gene Transfer Suppression Subtractive Hybridization Yersinia Pestis Francisella Tularensis Venezuelan Equine Encephalitis Virus 
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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Alexander Rakin
    • 1
  1. 1.Max von Pettenkofer-InstitutMunichGermany

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