Abstract
The use of appropriate mutants and an adequate enzyme analysis has enabled to decide which of these amino acids is synthesized first, since the final step in the pathway, the interconversion of serine and glycine, is catalyzed by a single enzyme, serine hydroxymethyltransferase, and since mutations affecting the biosynthesis of serine result in a nutritional requirement which can be satisfied by one or the other of these amino acids. However mutations deficient in hydroxymethyltransferase require specifically glycine and cannot grow with serine.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Selected References
Serine Biosynthesis
J.K. Bell, P.J. Pease, J.E. Bell, G.A. Grant and L.J. Banaszak, Eur. J. Biochem., 269, 4176–4184 (2002).
G. Hester, W. Stark, M. Moser, J. Kallen, Z. Markovic-Housley and J.N. Jansonius, J. Mol. Biol., 286, 829–50 (1999).
Serine Hydroxymethylase
L. Schirch, Advances in Enzymology, 53, 83–112 (1982).
G.V. Stauffer, in Amino acids: Biosynthesis and Genetic Regulation (K.M. Herrmann and R.L. Somerville, eds.), Addison-Wesley Publishing Company, Inc. Reading, Massachusetts, pp. 103–113 (1983).
J.N. Scarsdale, S. Radaev, G. Kazanina, V. Schirch and H.T. Wright, J. Mol. Biol., 296, 155–168 (2000).
Sulfite Reductase
L.M. Siegel, M.J. Murphy and H. Kamin, J. Biol. Chem., 248, 251–261 (1973).
I. Guillouard, S. Auger, M.F. Hullo, F. Chetouani, A. Danchin and I. Martin-Verstraete, J. Bacteriol., 184, 4681–4689 (2002).
Cysteine Synthesis in Methanogens
S. Helgadóttir, G. Rosas-Sandoval, D. Söll and D.E. Graham, J Bacteriol., 189, 575–582 (2007).
Valine and Leucine
H.E. Umbarger, in Escherichia coli and Salmonella typhimurium, Cellular and Molecular Biology, (J.L. Ingraham, K.B. Low, B. Magasanik, M. Schachter and H.E. Umbarger, eds.) American Society for Microbiology, pp. 352–367, Washington, D.C., (1987).
Isoleucine Synthesis from Pyruvate
R.M. Drevland, A.Waheed, and D.E. Graham, J Bacteriol, 189, 4391–4400 (2007).
Aspartate-β-Decarboxylase
S.S. Tate and A. Meister, Advances in Enzymology, 35, 503–543 (1971).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2010 Springer Netherlands
About this chapter
Cite this chapter
Cohen, G.N. (2010). Biosynthesis of Amino Acids Derived from Phosphoglyceric Acid and Pyruvic Acid. In: Microbial Biochemistry. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9437-7_29
Download citation
DOI: https://doi.org/10.1007/978-90-481-9437-7_29
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-9436-0
Online ISBN: 978-90-481-9437-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)