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Regulation of Mammalian Histamine Synthesis: Histidine Decarboxylase

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Book cover Biomedical Aspects of Histamine

Abstract

Histamine plays a wide variety of physiological and pathological responses, such as immediate allergy, inflammation, gastric acid secretion, neurotransmission, and immune modulation. Histamine synthesis is mediated by the enzyme, L-histidine decarboxylase (HDC), which catalyzes decarboxylation of L-histidine. In contrast to extensive investigation and development of specific antagonists for histamine receptors, regulation of histamine synthesis remains to be clarified. We review here a series of studies about regulation of histamine synthesis, with a particular attention to the rate-limiting enzyme, HDC. We describe and discuss about the findings on various aspects of HDC, such as transcriptional regulation, post-translational regulation, and novel functions identified with the gene targeted mouse strain for HDC. It should be surely required for better understanding of the physiological roles of histamine to clarify the regulation of histamine synthesis, since accumulating evidence has indicated the critical roles of newly-formed histamine in health and disease.

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Abbreviations

HDC:

histidine decarboxylase

ECL:

enterochromaffin-like

PACAP:

pituitary adenylyl cyclase-activating protein

CML:

chronic myeloid leukemia

GM-CSF:

granulocyte-macrophage colony stimulating factor

VMAT2:

vesicular monoamine transporter 2

PEST:

proline (P), glutamic acid (E), serine (S) and threonine (T)

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Authors and Affiliations

  1. Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Okayama, 700-8530, Japan

    Satoshi Tanaka

  2. Institute for Biosciences, Mukogawa Women’s University, Kyuban-cho 11-68, Nishinomiya, Hyogo, 663-8179, Japan

    Atsushi Ichikawa

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  1. Satoshi Tanaka
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  2. Atsushi Ichikawa
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Correspondence to Satoshi Tanaka .

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Editors and Affiliations

  1. School of Medicine, Dept. Internal Medicine, Southern Illinois University, N. Rutledge 751, Springfield, 62702, Illinois, USA

    Nancy Khardori

  2. J. N. Medical College, Dept. Pharmacology, Aligarh Muslim University, Aligarh, 202002, India

    Rahat Ali Khan

  3. Jawaharlal Nehru Medical College &, Hospital, Aligarh Muslim University, Aligarh, 202002, India

    Trivendra Tripathi

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Tanaka, S., Ichikawa, A. (2010). Regulation of Mammalian Histamine Synthesis: Histidine Decarboxylase. In: Khardori, N., Khan, R., Tripathi, T. (eds) Biomedical Aspects of Histamine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9349-3_2

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