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Roles for Actin Dynamics in Cell Movements During Development

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Actin-based Motility

Abstract

Actin-dependent cellular movements and rearrangements are crucial for development. Studies in vitro have contributed much to the knowledge of actin biology. However, interesting environmental influences common in developing systems can differentially regulate actin dynamics and organization. In this chapter, we highlight several selected examples of directed cell migration during morphogenesis, in which actin dynamics have been observed directly in live-imaging studies. We discuss similarities and differences between collective cell and single cell migration during development, and we compare what has been learned from in vivo studies in developmental systems with in vitro studies of single cells.

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Acknowledgements

We thank Mark Peifer, David Reiner, Stephanie Nowotarski, Erik Lundquist, and members of the Goldstein lab for comments on the manuscript. Work in the Goldstein lab on actin dynamics in morphogenesis is supported by NIH R01 GM083071.

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  1. Biology Department, UNC Chapel Hill, Chapel Hill, NC, 27599-3280, USA

    Minna Roh-Johnson, Jessica Sullivan-Brown & Bob Goldstein

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  1. Minna Roh-Johnson
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Correspondence to Minna Roh-Johnson .

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  1. , Laboratory of Structural Enzymology and, CNRS, Gif-sur-Yvette Cedex, 91198, France

    Marie-France Carlier

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Roh-Johnson, M., Sullivan-Brown, J., Goldstein, B. (2010). Roles for Actin Dynamics in Cell Movements During Development. In: Carlier, MF. (eds) Actin-based Motility. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9301-1_8

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