Abstract
Mathematical modeling has been very instrumental in aiding traditional experimental methods in uncovering the mysteries of actin dynamics. Here we review recent quantitative models of actin dynamics focusing on ATP hydrolysis effects, force generation by single actin filaments and networks, self-organization and dynamics of actin networks, dynamics of lamellipodia , filopodia and lamella, and integrative mechanochemistry of whole motile cells. We discuss both modeling methods and specific insights from modeling that helped answering biological questions.
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Abbreviations
- ADP:
-
adenosine diphosphate
- ATP:
-
adenosine triphosphate
- BR:
-
Brownian ratchet
- CCA:
-
cofilin, coronin, and Aip1
- CP:
-
capping protein
- F-actin:
-
filamentous or polymerized actin
- G-actin:
-
globular or unpolymerized actin
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Acknowledgements
This work was supported by NIH GLUE Grant “Cell Migration Consortium” (NIGMS U54 GM64346), by NSF Grant DMS-0315782 to A.M., and NIH Grant R01 GM086882 to A.E.C.
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Carlsson, A.E., Mogilner, A. (2010). Mathematical and Physical Modeling of Actin Dynamics in Motile Cells. In: Carlier, MF. (eds) Actin-based Motility. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9301-1_16
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