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The Effect of Bacterial Toxins on Platelet Function

  • Steven Kerrigan
  • Dermot Cox
Chapter

Abstract

While the ability of cell wall components of bacteria to interact with platelets has been well established there is also evidence that bacterial toxins have the potential to activate platelets. In particular pore-forming toxins such as pneumolysin, streptolysins and a-toxin can activate platelets probably in a manner similar to the calcium ionophore A23187. Cell wall components such as lipopolysaccharide and lipoteichoic acid can activate platelets via Toll-like receptors although evidence would suggest that this may be indirectly via leucocyte activation. Also, toxins such as Shiga toxin, superantigens, gingipains and M proteins can activate platelets. Ultimately the response of platelets to infection is likely to be due to both direct interaction with bacteria and exposure to secreted bacterial products.

Keywords

Platelet Activation Necrotizing Fasciitis Toxic Shock Syndrome Bacterial Toxin Shiga Toxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Molecular and Cellular TherapeuticsRoyal College of Surgeons in IrelandDublinIreland

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