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OZONE pp 17–26Cite as

How Does Ozone Act? How and Why Can We Avoid Ozone Toxicity?

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Abstract

This is one of the most important chapters because I believe that, if the ozonetherapist understands how ozone reacts with body fluids and cells, he can achieve useful therapeutic results. The administration of ozone causes a number of biochemical, pharmacological and psycho-neuro-immunological reactions to take place in a patient who is an essential part of the process.

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References

  • Alary, J., Geuraud, F., and Cravedi, J. P., 2003, Fate of 4-hydroxynonenal in vivo: disposition and metabolic pathways, Mol. Aspects Med. 24:177–187.

    CAS  PubMed  Google Scholar 

  • Aldini, G., Gamberoni, L., Orioli, M. et al., 2006, Mass spectrometric characterization of covalent modification of human serum albumin by 4-hydroxy-trans-2-nonenal, J. Mass Spectrom. 41:1149–1161.

    CAS  PubMed  Google Scholar 

  • Antunes, F., and Cadenas, E., 2000, Estimation of hydrogen peroxide gradient across biomembranes, FEBS Lett. 475:121–126.

    CAS  PubMed  Google Scholar 

  • Awasthi., Y. C., Ansari, G. A., and Awasthi, S., 2005, Regulation of 4-hydroxynonenal mediated signalling by gluthatione S-transferase, Methods Enzymol. 401:379–407.

    CAS  PubMed  Google Scholar 

  • Baeuerle, P. A., and Henkel, T., 1994, Function and activation of NF-kB in the immune system, Annu. Rev. Immunol. 12:141–179.

    CAS  PubMed  Google Scholar 

  • Barnes, P. J., and Karin, M., 1997, Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases, N. Engl. J. Med. 336:1066–1071.

    CAS  PubMed  Google Scholar 

  • Bocci, V., 2000, Ossigeno-ozono terapia, Casa Editrice Ambrosiana, Milano, pp. 1–324.

    Google Scholar 

  • Bocci, V., 2002, Oxygen-ozone therapy, a critical evaluation, Kluwer Academic Publischer, Dordrecht.

    Google Scholar 

  • Bocci, V., 2004, Ozone as Janus: this controversial gas can be either toxic or medically useful, Mediators Inflamm. 13:3–11.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bocci, V., and Aldinucci, C., 2006, Biochemical modifications induced in human blood by oxygenation-ozonation, J. Biochem. Mol. Toxicol. 20:133–138.

    CAS  PubMed  Google Scholar 

  • Bocci, V., and Paulesu, L., 1990, Studies on the biological effects of ozone 1. Induction of interferon gamma on human leucocytes, Haematologica 75:510–515.

    CAS  PubMed  Google Scholar 

  • Bocci, V., Borrelli, E., Valacchi, G., and Luzzi, E., 1999a, Quasi-total-body exposure to an oxygen-ozone mixture in a sauna cabin, Eur. J. Appl. Physiol. Occup. Physiol. 80:549–554.

    CAS  PubMed  Google Scholar 

  • Bocci, V., and Di Paolo., N., 2009, Oxygen-ozone therapy in medicine: an update, Blood Purif. 28:373–376.

    CAS  PubMed  Google Scholar 

  • Bocci, V., Luzzi, E., Corradeschi, F., Paulesu, L., and Di Stefano, A., 1993a, Studies on the biological effects of ozone: 3. An attempt to define conditions for optimal induction of cytokines, Lymphokine Cytokine Res. 12:121–126.

    CAS  PubMed  Google Scholar 

  • Bocci, V., Luzzi, E., Corradeschi, F., Paulesu, L., Rossi, R., Cardaioli, E., and Di Simplicio, P., 1993b, Studies on the biological effects of ozone: 4. Cytokine production and glutathione levels in human erythrocytes, J. Biol. Regul. Homeost. Agents 7:133–138.

    CAS  PubMed  Google Scholar 

  • Bocci, V., Valacchi, G., Corradeschi, F., Aldinucci, C., Silvestri, S., Paccagnini, E., and Gerli, R., 1998a, Studies on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone, J. Biol. Regul. Homeost. Agents 12:67–75.

    CAS  PubMed  Google Scholar 

  • Bocci, V., Valacchi, G., Corradeschi, F., and Fanetti, G., 1998b, Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production, Mediators Inflamm. 7:313–317.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bustamante, J., Lodge, J. K., Marcocci, L., Tritschler, H., Packer, L., and Rihn, B. H., 1998, a-lipoic acid in liver metabolism and disease, Free Radic. Biol. Med. 24:1023–1039.

    CAS  PubMed  Google Scholar 

  • Chae, H. Z., Kim, K., and Kim, I.-H., 1999, The novel antioxidant enzyme, thioredoxin peroxidase, and mammalian peroxiredoxins. in Redox regulation of cell signaling and its clinical application (L. Packer, and J. Yodoi, Eds), Marcel Dekker, Inc., New York, NY, pp. 85–92.

    Google Scholar 

  • Chow, C. K., and Kaneko, J. J., 1979, Influence of dietary vitamin E on the red cells of ozone-exposed rats, Environ. Res. 19:49–55.

    CAS  PubMed  Google Scholar 

  • Di Mascio, P., Kaiser, S., and Sies, H., 1989, Lycopene as the most efficient biological carotenoid singlet oxygen quencher, Arch. Biochem. Biophys. 274:532–538.

    PubMed  Google Scholar 

  • Forman, H. J., 2008, Hydrogen peroxide: the good, the bad and the ugly, in Oxidants in Biology (G. Valacchi, and P. Davis, Eds.), Springer, Dordrecht, The Netherlands, pp. 1–17.

    Google Scholar 

  • Frei, B., 1999, On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction, Proc. Soc. Exp. Biol. Med. 222:196–204.

    CAS  PubMed  Google Scholar 

  • Fridovich, I., 1995, Superoxide radical and superoxide dismutases, Annu. Rev. Biochem. 64:97–112.

    CAS  PubMed  Google Scholar 

  • Halliwell, B., 1994, Free radicals and antioxidants: a personal view, Nutr. Rev. 52:253–265.

    CAS  PubMed  Google Scholar 

  • Halliwell, B., 1999a, Antioxidant defence mechanisms: from the beginning to the end (of the beginning), Free Radic. Res. 31:261–272.

    CAS  PubMed  Google Scholar 

  • Halliwell, B., 1999b, Vitamin C: poison, prophylactic or panacea? Trends Biochem. Sci. 24:255–259.

    CAS  PubMed  Google Scholar 

  • Halliwell, B., 2001, Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment, Drugs Aging 18:685–716.

    CAS  PubMed  Google Scholar 

  • Halliwell, B., Clement, M. V., and And Long, L. H., 2000a, Hydrogen peroxide in the human body, FEBS Lett. 486:10–13.

    CAS  PubMed  Google Scholar 

  • Halliwell, B., Zhao, K., and Whiteman, M., 2000b, The gastrointestinal tract: a major site of antioxidant action? Free Radic. Res. 33:819–830.

    CAS  PubMed  Google Scholar 

  • Holmgren, A., 1989, Thioredoxin and glutaredoxin systems, J. Biol. Chem. 264:13963–13966.

    CAS  PubMed  Google Scholar 

  • Hooper, D. C., Scott, G. S., Zborek, A., Mikheeva, T., Kean, R. B., Koprowski, H., and Spitsin, S. V., 2000, Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood- CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis, FASEB J. 14:691–698.

    CAS  PubMed  Google Scholar 

  • Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W., Fong, H. H., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., and Pezzuto, J. M., 1997, Cancer chemopreventive activity of resveratrol, a natural product derived from grapes, Science 275:218–220.

    CAS  PubMed  Google Scholar 

  • Kowaltowski, A. J., de Souza-Pinto, N. C., Castilho, R. F. et al., 2009, Mitochondria and reactive oxygen species, Free Radic. Biol. Med. in press, May 7.

    Google Scholar 

  • Mendiratta, S., Qu, Z.-C., and May, J. M., 1998a, Erythrocyte ascorbate recycling: antioxidant effects in blood, Free Radic. Biol. Med. 24:789–797.

    CAS  PubMed  Google Scholar 

  • Mendiratta, S., Qu, Z.-C., and May, J. M., 1998b, Enzyme-dependent ascorbate recycling in human erythrocytes: role of thioredoxin reductase, Free Radic. Biol. Med. 25:221–228.

    CAS  PubMed  Google Scholar 

  • Packer, L., Roy, S., and Sen, C. K., 1997, Alpha-lipoic acid: a metabolic antioxidant and potential redox modulator of transcription, Adv. Pharmacol. 38:79–101.

    CAS  PubMed  Google Scholar 

  • Pryor, W. A., Squadrito, G. L., and Friedman, M., 1995, The cascade mechanism to explain ozone toxicity: the role of lipid ozonation products, Free Radic. Biol. Med. 19:935–941.

    CAS  PubMed  Google Scholar 

  • Pullar, J. M., Vissers, M. C., and Winterbourn, C. C., 2000, Living with a killer: the effects of hypochlorous acid on mammalian cells, IUBMB. Life 50:259–266.

    CAS  PubMed  Google Scholar 

  • Reth, M., 2002, Hydrogen peroxide as second messenger in lymphocyte activation, Nat. Immunol. 3:1129–1134.

    CAS  PubMed  Google Scholar 

  • Rhee, S. G., Bae, Y. S., Lee, S. R., and Kwon, J., 2000, Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation, Sci. STKE 53:PE1, October 10.

    Google Scholar 

  • Siems, W., and Grune, T., 2003, Intracellular metabolism of 4-hydroxynonenal, Mol. Aspects Med. 24:167–175.

    CAS  PubMed  Google Scholar 

  • Stone, J. R., and Collins, T., 2002, The role of hydrogen peroxide in endothelial proliferative responses, Endothelium 9:231–238.

    CAS  PubMed  Google Scholar 

  • Stone, J. R., and Yang, S., 2006, Hydrogen peroxide: a signalling messenger, Antioxid. Redox Signal 8:243–270.

    CAS  PubMed  Google Scholar 

  • Yamamoto, Y., 2000, Fate of lipid hydroperoxides in blood plasma, Free Radic. Res. 33:795–800.

    CAS  PubMed  Google Scholar 

  • Travagli, V., Zanardi, I., Bernini, P., et al., 2010b, Effects of ozone blood treatment on the metabolite profile of human blood. Int. J. Toxicol. 29:165–174.

    CAS  PubMed  Google Scholar 

  • Poli, G., Schaur, R. J., Siems, W. G., and Leonarduzzi, G., 2008, 4-hydroxynonenal: a membrane lipid oxidation product of medicinal interest, Med. Res. Rev. 28:569–631.

    CAS  PubMed  Google Scholar 

  • Dianzani, M. U., 1998, 4-Hydroxynonenal and cell signalling, Free Radic. Res. 28:553–560.

    CAS  PubMed  Google Scholar 

  • Parola, M., Bellomo, G., Robino, G., Barrera, G., and Dianzani, M. U., 1999, 4-Hydroxynonenal as a biological signal: molecular basis and pathophysiological implications, Antiox. Redox Signal. 1:255–284.

    CAS  Google Scholar 

  • Bosch-Morell, F., Flohé, L., Marìn, N., and Romero, F. J., 1999, 4-hydroxynonenal inhibits glutathione peroxidase: protection by glutathione, Free Radic. Biol. Med. 26:1383–1387.

    CAS  PubMed  Google Scholar 

  • Larini, A., Bianchi, L., and Bocci, V., 2004, Effect of 4-hydroxynonenal on antioxidant capacity and apoptosis induction in Jurkat T cells, Free Radic. Res. 38:509–516.

    CAS  PubMed  Google Scholar 

  • Aldini, G., Vistoli, G., Regazzoni, L., et al., 2008, Albumin is the main nucleophilic target of human plasma: a protective role against pro-atherogenic electrophilic reactive carbonyl species? Chem. Res. Toxicol. 21:824–835.

    CAS  PubMed  Google Scholar 

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Bocci, V. (2010). How Does Ozone Act? How and Why Can We Avoid Ozone Toxicity?. In: OZONE. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9234-2_4

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  • DOI: https://doi.org/10.1007/978-90-481-9234-2_4

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  • Print ISBN: 978-90-481-9233-5

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