Summary and Outlook

  • Kurt Hellmann
  • Walter Rhomberg


Razoxane (Rz) and dexrazoxane (DXRz) have several interesting modes of action. They block the cell division at the level of G2/M in the cell cycle, they have shown antiinvasive activity in preclinical experiments, and they are able to normalize pathological tumour blood vessels. In addition, the drugs inhibit topoisomerase II α (the full implications have yet to emerge) and they are powerful chelating agents which not only chelate iron, but also a variety of other ions such as zinc, magnesium, lead, cadmium and copper.


Diabetic Retinopathy Soft Tissue Sarcoma Vinca Alkaloid Dimethyl Hydrazine Preclinical Experiment 
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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Kurt Hellmann
    • 1
  • Walter Rhomberg
    • 2
  1. 1.Windleshaw HouseWithyhamUK
  2. 2.BludenzAustria

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