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The Development of a Stem Cell Therapy for Deafness

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Regenerative Medicine

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Abstract

Medicine is at the doorsteps of a phenomenal revolution, brought by the advances in the stem cell field and the development of new technologies to engineer cells and tissues into more complex organs. The promise of a true regenerative approach to organ damage and loss of function is closer than ever of becoming a reality. The auditory field is participating of these developments with high ­expectations. Since the cochlea is an organ of difficult access and with very limited regenerative capacity, conventional therapeutic approaches have failed and, currently, the only treatments available are in the form of hearing aids and cochlear implants. The potential restoration of hearing by the use of exogenous stem cells will offer a solution to a condition that has very limited options. In this chapter, we are reviewing the increasing volume of research on this emerging field and discussing the key elements that need to be developed further, in order to translate the basic science into a clinical reality.

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Acknowledgements

This work was supported by grants from the Royal National Institute for Deaf People (RNID) to MR

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  1. Centre for Stem Cell Biology and Department of Biomedical Sciences, University of Sheffield, Addison Bldg, Western Bank, S10 2TN, Sheffield, UK

    Nopporn Jongkamonwiwat & Marcelo N. Rivolta

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Correspondence to Marcelo N. Rivolta .

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  1. Klinik und Poliklinik für Herzchirurgie, Universitätsklinikum Rostock, Schillingallee 35, Rostock, 18057, Germany

    Gustav Steinhoff

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Jongkamonwiwat, N., Rivolta, M.N. (2011). The Development of a Stem Cell Therapy for Deafness. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9075-1_27

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