History of Regenerative Medicine

  • Raymund E. Horch
  • Laurentiu M. Popescu
  • Elias Polykandriotis


Generation and regeneration as an answer to disease are far from being a new idea. Philosophers, naturalists and scientists were intrigued by the marvels of regeneration seen in nature. By the middle of the nineties life scientists thought we were only a few years away from bioartificial organs grown in a Petri dish. However, by the dawn of the new millennium it became clear that the mechanistic approach dictated by tissue engineering so far, had neglected issues of vascularization. Processes of angiogenesis were central to homeostasis, bioassimilation and biointegration of tissue engineered constructs. Furthermore, the field of tissue engineering had evolved into something vast, encompassing satellite technologies that were becoming separate science sectors. Advances in genetical engineering, stem cell biology, cloning, biomaterials and biomedical devices to name a few, would come to play a major role of their own – tissue engineering had become a part of a bigger whole. Regenerative medicine is the collective field to shelter these technologies “…that seeks to develop functional cell, tissue, and organ substitutes to repair, replace or enhance biological function that has been lost due to congenital abnormalities, injury, disease, or aging”


Tissue Engineering Eighteenth Century Regenerative Medicine Stem Cell Research Tissue Engineer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Netherlands 2011

Authors and Affiliations

  • Raymund E. Horch
    • 1
  • Laurentiu M. Popescu
    • 2
    • 3
  • Elias Polykandriotis
    • 1
  1. 1.Department of Plastic and Hand SurgeryUniversity of ErlangenErlangenGermany
  2. 2.“Victor Babes”, National Institute of PathologyBucharestRomania
  3. 3.Department of Cellular and Molecular Medicine“Carol Davila” University of Medicine and PharmacyBucharest 35Romania

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