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Current Research of the RAS in Pancreatitis and Pancreatic Cancer

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The Renin-Angiotensin System: Current Research Progress in The Pancreas

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 690))

Abstract

A local RAS exists in several cell types of the pancreas, which exhibits both exocrine and endocrine activities, and this functional local RAS is responsive to various physiological and pathophysiological stimuli (see Chapter 6). Of particular interest in this context are the expression and localization of key RAS components in the acinar and endothelial cells of the exocrine pancreas; these RAS components are subject to upregulation in response to chronic hypoxia and acute pancreatitis (AP). In this regard, an enhanced sensitivity of angiotensin II-mediated vasoconstriction in pancreatic microcirculation could trigger severe ischemia and/or hypoxia conditions, which result in oxidative stress-induced expression of proinflammatory factors, ultimately leading to pancreatic cell inflammation and injury. Indeed, recent investigations have demonstrated that inhibition of RAS activation supports amelioration of pancreatic oxidative stress and tissue injury in experimentally induced AP.

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  1. School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong, Shatin, Hong Kong, China

    Po Sing Leung PhD

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Leung, P.S. (2010). Current Research of the RAS in Pancreatitis and Pancreatic Cancer. In: The Renin-Angiotensin System: Current Research Progress in The Pancreas. Advances in Experimental Medicine and Biology, vol 690. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9060-7_10

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