Inhibitors of Innate Immunity from Vaccinia Virus

  • Geoffrey L. Smith
Conference paper


Vaccinia virus (VACV) is an enigma, for it is the only vaccine to have eradicated a human disease, smallpox, and yet its origin and natural host remain unknown. After the eradication of smallpox, VACV has continued to be studied intensively because of the potential use of recombinant VACVs as vaccines against other infectious diseases, and because it is an excellent model for studying virus-host interactions. This short article considers some of the strategies used by VACV to suppress the host innate immune response to infection. These strategies include proteins that are secreted from infected cells to bind complement factors, cytokines, chemokines or interferons, and intracellular proteins that can synthesize steroid hormones, or block apoptosis or innate signalling pathways leading to production of inflammatory mediators.


Synthesize Steroid Hormone Surface Groove Smallpox Vaccine Myxoma Virus Innate Immune Signalling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The author is most grateful to the conference organisers for the kind invitation to visit Israel and attend the 46th Oholo Conference. The work in the author’s laboratory has been supported by grants from the Wellcome Trust, the Medical Research Council of UK. GLS is a Wellcome Principal Research Fellow.


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Department of Virology, Faculty of MedicineImperial College LondonLondonEngland

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