Toxoplasma gondii

  • Neisha Jeoffreys


Traditionally, Toxoplasma gondii encephalitis was diagnosed using brain radioimaging techniques, culture and serology. Mouse inoculation is the ‘gold standard’ but is rarely performed these days and culture in cell lines is relatively slow and lacks sensitivity [3]. Serology is often used but it may be difficult to differentiate between past and current infection [6] and immunocompromised hosts may have a variable serological response. The detection of ring enhancing lesions in the brain by radioimaging is often used as an indicator of toxoplasmosis, however these signs may also be seen in lymphoma [4] and there are atypical presentations which make diagnosis difficult [5].


Paraffin Embed Vitreous Fluid Hydrolysis Probe Ocular Toxoplasmosis Ring Enhance Lesion 
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  1. 1.
    Filisetti D, Gorcii M, Pernot-Marino E et al (2003) Diagnosis of congenital toxoplasmosis: comparison of targets for detection of Toxoplasma gondii by PCR. J Clin Microbiol 41:4826–4828PubMedCrossRefGoogle Scholar
  2. 2.
    Homan WL, Vercammen M, De Braekeleer J et al (2000) Identification of a 200- to 300-fold repetitive 529 bp DNA fragment in Toxoplasma gondii, and its use for diagnostic and quantitative PCR. Int J Parasitol 30:69–75PubMedCrossRefGoogle Scholar
  3. 3.
    James GS, Sintchenko VG, Dickeson DJ et al (1996) Comparison of cell culture, mouse inoculation, and PCR for detection of Toxoplasma gondii: effects of storage conditions on sensitivity. J Clin Microbiol 34:1572–1575PubMedGoogle Scholar
  4. 4.
    Masamed R, Meleis A, Lee EW et al (2009) Cerebral toxoplasmosis: case review and description of a new imaging sign. Clin Radiol 64:560–563PubMedCrossRefGoogle Scholar
  5. 5.
    Ramsey RG, Gean AD (1997) Neuroimaging of AIDS. I. Central nervous system toxoplasmosis. Neuroimag Clin N Am 7:171–186Google Scholar
  6. 6.
    Remington JS, Thulliez P, Montoya JG (2004) Recent developments for diagnosis of toxoplasmosis. J Clin Microbiol 42:941–945PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Molecular BiologyCentre for Infectious Diseases and Microbiology, Institute for Clinical Pathology and Medical Research, Westmead HospitalWestmeadAustralia

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