Fredrickson’s Classification of the Hyperlipoproteinaemias

  • A. Stewart Truswell


Serum lipids can be raised in association with several diseases, such as hypothyroidism and nephrotic syndrome (secondary hyperlipidaemia). Hypercholesterolaemia or hypertriglyceridaemia may also be primary, probably genetic. Fredrickson (1967) classified and described hyperlipidaemias, based on which classes of lipoprotein were elevated, so hyperlipoprotinaemias. Paper electrophoresis of lipoprotein was added to measurement of serum cholesterol and triglycerides. He described five types of hyperlipoprotinaemias, Types I to V. They require different management. Subsequently (1970) type II (hypercholesterolaemia) was subdivided into IIA or IIB – the latter accompanied by raised triglycerides. In 1972 familial combined hyperlipidaemia was defined. Years 1967–1973.


Nephrotic Syndrome Familial Hypercholesterolaemia Combine Hyperlipidaemia Paper Electrophoresis Inherit Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Human Nutrition UnitUniversity of SydneySydneyAustralia

Personalised recommendations