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Role of Spatial Distribution of Matricellular Cues in Controlling Cell Functions

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Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles

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Abstract

The extracellular matrix (ECM) represents the quintessential material for tissue engineering (TE) applications, because it provides a structural support and regulates tissue development. Therefore, the main challenge in TE is to recreate ECM analogues that recapitulate the structural and molecular microenvironment to promote and guide tissue growth. Apart from composition, the distribution and presentation of molecular cues within the matrix are pivotal in controlling morphogenetic process. However, the role of matricellular signal presentation in terms of spatial and temporal orchestration is still poorly understood. This article overviews the development of systems able to control the spatial and temporal exposure of matricellular cues to the aim of guide cell response for tissue engineering applications.

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  1. Department of Materials and Production Engineering, University of Naples “Federico II”, P.le Tecchio 80, 80125, Naples, Italy

    Daniela Guarnieri & Paolo A. Netti

  2. Interdisciplinary Research Centre on Biomaterials (CRIB), University of Naples “Federico II”, P.le Tecchio 80, 80125, Naples, Italy

    Daniela Guarnieri & Paolo A. Netti

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Correspondence to Paolo A. Netti .

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  1. Inst. Makromolekulare Chemie, Zentrum für Biologische Signalstudien, Universität Freiburg, Stefan-Meier-Str. 31, Freiburg, 79104, Germany

    Venkatram Prasad Shastri

  2. Avançats (ICREA), Instituciò Catalana de Recerca i Estudis, Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907, Spain

    George Altankov

  3. Geesthacht GmbH, Institut für Chemie, GKSS Forschungszentrum, Kantstraße 5, Teltow, 14513, Germany

    Andreas Lendlein

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Guarnieri, D., Netti, P.A. (2010). Role of Spatial Distribution of Matricellular Cues in Controlling Cell Functions. In: Shastri, V., Altankov, G., Lendlein, A. (eds) Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8790-4_11

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