Anti-vascular Therapy for Brain Tumors

  • Florence M. Hofman
  • Thomas C. Chen
Part of the Methods of Cancer Diagnosis, Therapy and Prognosis book series (HAYAT, volume 8)


The formation of new blood vessels, a ­normal process in fetal development, wound healing and during the menstrual cycle, functions to provide expanding tissues with nutrients, oxygen, and waste removal. The extent of vasculature development defines the survival and growth of tissues. Tumor growth also depends on the expansion of the vasculature. Tumor cells can survive only within a specific distance from the blood vessels; beyond this point the cells become hypoxic and die (Hlatky et al. 2002). In the absence of a parallel expansion of the blood supply, the tumor will stop growing and remain dormant for years or die (Folkman 2007). Studies suggest that activation of the dormant tumor cells cause a change in the balance of pro- and anti-angiogenic factors present in the tumor microenvironment, triggering the blood vessels in the surrounding normal tissue to become activated and invade the tumor (angiogenesis) (Folkman 2007)


Vascular Endothelial Growth Factor Focal Adhesion Kinase Endothelial Progenitor Cell Tumor Vasculature Epithelial Growth Factor Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Netherlands 2011

Authors and Affiliations

  1. 1.Department of Pathology, Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA

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