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Cyclic AMP Phosphodiesterase-4 in Brain Tumor Biology: Immunochemical Analysis

  • B. Mark Woerner
  • Joshua B. Rubin
Chapter
Part of the Methods of Cancer Diagnosis, Therapy and Prognosis book series (HAYAT, volume 8)

Abstract

Central to advancing the care for patients with malignant neoplasms are efforts to delineate how cancer cells differ from their normal counterparts, and the identification of biological targets whose activity, when normalized, corrects the cancer phenotype and re-establishes normal growth control. In this regard we and others have described the tumor promoting actions of cyclic adenosine monophos­phate (cAMP) phosphodiesterases and the antitumor effects of phosphodiesterase inhibitors. In the following chapter we will focus on the unique biology of the cAMP phosphodiesterase-4 (PDE4) family of cAMP hydrolases as it pertains to brain tumors and the experimental challenges that arise when studying patterns of PDE4 expression.

Keywords

PDE4 Activity DAOY Cell Normal Swine Serum PDE4 Isoforms PDE4 Family 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements. The authors thank Nicole Warrington for critical reading of the manuscript. This work was supported by the NCI/NIH (CA118389) to JBR.

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Copyright information

© Springer Netherlands 2011

Authors and Affiliations

  • B. Mark Woerner
    • 1
  • Joshua B. Rubin
    • 1
  1. 1.Division of Pediatric Hematology/Oncology, Department of PediatricsWashington University, School of MedicineSt. LouisUSA

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