Diagnosing and Grading of Brain Tumors: Immunohistochemistry

  • Hidehiro TakeiEmail author
  • Suzanne Z. Powell
Part of the Methods of Cancer Diagnosis, Therapy and Prognosis book series (HAYAT, volume 8)


Diagnostic neuro-oncology practice has benefited in the last 2 decades from the incorporation of, and recent advances in, immunohistochemistry (IHC). Although the mainstay of brain tumor diagnosis including its grading remains conventional hematoxylin-eosin (H&E)-stained histology, it is no doubt that IHC plays a major role in differential diagnosis and in improving the diagnostic accuracy. It is generally used for purposes of (1) identifying tumor cell type/origin, (2) assessing cell proliferation potential, (3) evaluating the boundary between tumor and the surrounding tissue (i.e., tumor “margin”), and (4) excluding reactive processes (e.g., demyelinating and infectious diseases). In the future, novel antibodies utilized as prognostic, predictive markers and as potential therapeutic targets for brain tumors will be developed.


Glial Fibrillary Acidic Protein Pilocytic Astrocytoma Epithelial Membrane Antigen Solitary Fibrous Tumor Central Neurocytoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Netherlands 2011

Authors and Affiliations

  1. 1.Department of PathologyBaylor College of MedicineHoustonUSA

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