Regioselective Synthesis of Polyfluorinated Pyrazoles and Evaluation of Antimicrobial Activity

  • Madhukar N. Jachak
  • Dilip R. Birari
  • Deepak P. Shelar
  • Sandeep R. Patil
  • Ramhari V. Rote
  • Santosh S. Shinde
  • Sandip M. Bagul


A series of 1,3,5-trisubstituted pyrazole derivatives were prepared from one asymmetrical polyfluorinated 1,3-diketone. The reactivity of substituted hydrazines towards the diketone compound is studied leading to the formation of regioisomers. The polyfluorinated pyrazoles were utilized for the alkylation with N-aryl acetamides to yield N-alkyl products. Then they were hooked with amino acid esters such as L-phenylalanine, L-proline, L-tyrosine, and L-norvaline by multistep process. The antimicrobial activities of the synthesized pyrazoles were evaluated. All synthesized compounds were characterized by spectroscopic and analytical methods.


Reaction Mass Colorless Needle Pyrazole Derivative Pure Fraction Amino Acid Ester 
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The authors gratefully acknowledge financial support of this project by UGC, New Delhi, BCUD, University of Pune, India and Principal, K. T. H. M. College, Nashik – 422 002 for facilities.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Madhukar N. Jachak
    • 1
  • Dilip R. Birari
    • 1
  • Deepak P. Shelar
    • 1
  • Sandeep R. Patil
    • 1
  • Ramhari V. Rote
    • 1
  • Santosh S. Shinde
    • 1
  • Sandip M. Bagul
    • 1
  1. 1.Organic Chemistry Research Centre, Department of ChemistryK. T. H. M. CollegeNashikIndia

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