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Synthesis, Spectral Characterization and Anticancer Screening of Triorganotin(IV) Carboxylates

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Chemistry for Sustainable Development

Abstract

Triorganotin(IV) carboxylates of general formula, R3Sn(XA) [where R = Me, n-Bu and Ph] and XA = anion of hippuric acid (HHA), lauric acid (HLA), stearic acid (HSA) and myristic acid (HMA)] have been synthesized. The bonding and coordination behavior in these derivatives are discussed on the basis of elemental analysis, FT-IR, 1H, 13C and 119Sn NMR spectroscopic studies, which suggest that the ligands are coordinated through COO group acquiring trigonal-bipyramidal geometry around tin with the R groups in the equatorial positions, the carboxylic oxygen and the carbonyl oxygen atom of adjacent molecule occupying the axial positions. These carboxylates have been screened in vitro against five cancer cell lines of human origin. Ph3SnLA is the most active compound which exhibits potent anticancer activity against all the cell lines as compared to cis-platin. Furthermore, DNA ladder formation indicates that these compounds inhibit the cancer cell growth through apoptosis which has been confirmed by enzyme assays like lactate dehydrogenase, glutathione sulfur-transferase, glutathione reductase, glutathione-peroxidase, total glutathione content and lipid peroxidase assay.

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Acknowledgement

Ms. Monika Vats (JRF) is thankful to MHRD for the financial support.

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Correspondence to Mala Nath .

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Nath, M., Vats, M., Roy, P. (2012). Synthesis, Spectral Characterization and Anticancer Screening of Triorganotin(IV) Carboxylates. In: Gupta Bhowon, M., Jhaumeer-Laulloo, S., Li Kam Wah, H., Ramasami, P. (eds) Chemistry for Sustainable Development. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8650-1_18

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