Diseases of the Blood and Blood-Forming Organs

  • Nándor Ács
  • Ferenc G. Bánhidy
  • Andrew E. Czeizel


There is normally a 36% increase in the blood volume during pregnancy with a maximum at the 34th gestational week (Peck and Arias, 1979). This dramatic change is caused by the 47% plasma volume increase and 17% red blood cell mass increase. The latter reaches its maximum at term. This difference results in a relative hemodilution throughout pregnancy with a maximum between 18th and 34th gestational weeks.


Pregnant Woman Folic Acid Iron Deficiency Prenatal Care Birth Outcome 
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  1. Alper BS, Kimber R, Reddy AK. Using ferritin levels to determine irondeficiency anemia in pregnancy. J Fam Oract 2000; 49: 829–832.Google Scholar
  2. Bondevik GT, Lie RT, Ulstein M et al. Maternal hematological status and risk of low birth weight and preterm delivery in Nepal. Acta Obstet Gynaecol Scand 2001; 80: 402–408.CrossRefGoogle Scholar
  3. Burlingame J, McGaraghan A, Kilpatrick S et al. Maternal and fetal outcomes in pregnancies affected by von Willebrand disease type 2. Am J Obstet Gynecol 2001; 184: 229–230.PubMedCrossRefGoogle Scholar
  4. CDC: Centers for Disease Control and Prevention. Recommendation to prevent and control iron deficiency anemia in the Unites States MMWR (Morb Mortal Wkly Rep) 1988; 47: 1–29.Google Scholar
  5. Goldenberg RJ, Tamura T, DuBard M et al. Plasma ferritin and pregnancy outcome. Am J Obstet Gynecol 1996; 175: 1356–1359.PubMedCrossRefGoogle Scholar
  6. Kilpatrick SJ, Laros RK. Maternal hematologic disorders. In: Creasy RK, Resnik R, Iams JD (eds.) Maternal-Fetal Medicine. 5th ed. Saunders, Philadelphia, 2004. pp. 975–1004.Google Scholar
  7. Klebanoff MA, Shiono PH, Shelby JV et al. Anemia and spontaneous preterm birth. Am J Obstet Gynecol 1991; 164: 59–63.PubMedGoogle Scholar
  8. Laros RK Jr (ed.) Blood Disorders in Pregnancy. Lea and Febiger, Philadelphia, 1986.Google Scholar
  9. Lu ZM, Goldenberg RL, Cliver SP et al. The relationship between maternal hematocrit and pregnancy outcomes. Obstet Gynecol 1991; 77: 190–194.PubMedCrossRefGoogle Scholar
  10. Peck TM, Arias F. Hematologic changes associated with pregnancy. Clin Obstet 1979; 22: 785–798.CrossRefGoogle Scholar
  11. Pritchard JA, Whalley PJ, Scott DE. The influence of maternal folate and iron deficiency on intrauterine life. Am J Obstet Gynecol 1969; 104: 388–396.PubMedGoogle Scholar
  12. Sagen N, Nilsen ST, Kim HC et al. Maternal hemoglobin concentration is closely related to birth weight in normal pregnancy. Acta Obstet Gynaecol Scand 1984; 63: 245–248.CrossRefGoogle Scholar
  13. Scanlon KS, Yip R, Schieve LA, Cogswell ME. High and low hemoglobin levels during pregnancy. Differential risks for preterm birth and small for gestational age. Obstet Gynecol 2000; 96: 741–748.PubMedCrossRefGoogle Scholar
  14. Scholl TO, Hediger ML, Fischer RL et al. Anemia vs. iron deficiency: Increased risk of preterm delivery in a prospective study. Am J Clin Nutr 1992; 55: 985–988.PubMedGoogle Scholar
  15. Scott DE, Pritchard JA. Iron deficiency in healthy young college women.JAMA (J Am Med Ass) 1967; 199: 147–150.Google Scholar
  16. Stephansson O, Dickman PW, Johansson A et al. Maternal hemoglobin concentration during pregnancy and risk of stillbirth.JAMA (J Am Med Ass) 2000; 284: 2611–2617.CrossRefGoogle Scholar
  17. Welsh A. Hyperemesis, gastrointestinal and liver disorders in pregnancy. Curr Obstet Gynaecol 2005; 15: 123–131.CrossRefGoogle Scholar
  18. Williamson C. Gastrointestinal disease. Best Pract Res Clin Obstet Gynaecol 2001; 15(5): 937–952.PubMedCrossRefGoogle Scholar
  19. Xiong X, Buekens P, Alexander S et al. Anemia during pregnancy and birth outcomes: a meta-analysis. Am J Perinatol 2000; 17: 137–146.PubMedCrossRefGoogle Scholar

Own Publications

  1. I.
    Bánhidy F, Ács N, Puho HE, Czeizel AE. Iron deficiency anemia: Pregnancy outcomes with or without iron supplement. Nutrition 2010 (in press).Google Scholar
  2. II.
    Czeizel AE, István L. Spherocytosis with autosomal dominant inheritance (Hungarian with English abstract) Medicus Universalis 1998; 31: 17–21.Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Nándor Ács
    • 1
  • Ferenc G. Bánhidy
    • 1
  • Andrew E. Czeizel
    • 2
  1. 1.Second Department of Obstetrics and GynecologySemmelweis UniversityBudapestHungary
  2. 2.Foundation of the Community Control of Hereditary DiseasesBudapestHungary

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