The Hungarian Congenital Abnormality Registry (HCAR)

  • Nándor Ács
  • Ferenc G. Bánhidy
  • Andrew E. Czeizel


The HCAR was established in 1962 as the first national-based registry in the world (I), after the greatest tragedy of human teratology, the thalidomide-Contergan catastrophe. After a pilot period, the HCAR started to work according to the internationally recommended principles under my direction as part of the Department of Human Genetics and Teratology, National Institute of Public Health (NIPH) in 1980 (Fig. 1.1). The HCAR had a budget from the Ministry of Health for the salary of the staff, computer work, printing, and mailing costs. Extra projects needed special funds.


Down Syndrome Maternal Disease Orofacial Cleft Limb Deficiency Teratogenic Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Own Publications

  1. I.
    Czeizel A. First 25 years of the Hungarian Congenital Abnormality Registry. Teratology 1997; 55: 299–305.PubMedCrossRefGoogle Scholar
  2. II.
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  3. III.
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  4. IV.
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  5. V.
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  6. VI.
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  7. VII.
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  8. VIII.
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  9. IX.
    Czeizel AE, The activities of the Hungarian Centre for Congenital Anomaly Control. WHO Stat Quart Rep 1988; 41: 219–227.Google Scholar
  10. X.
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  11. XI.
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  12. XII.
    Czeizel AE, Tusnady G. Aetiological Studies of Isolated Common Congenital Abnormalities in Hungary. Akadémiai Kiadó, Budapest, 1984.Google Scholar
  13. XIII.
    Czeizel A. Epidemiological studies of congenital abnormalities in Hungary. In: Kalter H (ed.) Issues and Reviews in Teratology 1993; 6: 85–124.Google Scholar
  14. XIV.
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  15. XV.
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  16. XVI.
    Czeizel AE, Petik D, Puhó E. Smoking and alcohol drinking during pregnancy: the validity of retrospective maternal self-reported information. Centr Eur J Publ Health 2004; 12: 179–183.Google Scholar
  17. XVII.
    Czeizel AE, Gidai J, Petik D, Timmermann G, Puho H. Self-poisoning during pregnancy as a model for teratogenic estimation of drugs. Toxic Indust Health 2008; 24: 11–28.CrossRefGoogle Scholar
  18. XVIII.
    Czeizel AE, Tóth M. Birth weight, gestational age and medications during pregnancy. Int J Gynecol Obstet 1998; 60: 245–249.CrossRefGoogle Scholar
  19. XIX.
    Czeizel AE, Pazonyi I. Increase of upper-limb-reduction deformities in Hungary. Lancet 1976; 1: 701.PubMedCrossRefGoogle Scholar
  20. XX.
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  21. XXI.
    Czeizel AE, Elerk Cs, Gundy S, Métneki J, Nemes E, Reis K, Sperling K, Timár L, Tusnády G. Virágh Z. Environmental trichlorfon and cluster of congenital abnormalities. Lancet 1993; 34: 539–542.CrossRefGoogle Scholar
  22. XXII.
    Czeizel AE, Rockenbauer M, Siffel Cs, Varga E. Description and mission evaluation of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980–1996. Teratology 2001; 63: 176–185.PubMedCrossRefGoogle Scholar
  23. XXIII.
    Czeizel A. The role of pharmacoepidemiology in pharmacovigilance: rational drug use in pregnancy. Pharmacoepid Drug Saf 1999; 8: 555–561.Google Scholar
  24. XXIV.
    Czeizel A. Drug use during pregnancy in Hungary. Acta Med Hung 1989; 46: 53–62.PubMedGoogle Scholar
  25. XXV.
    Czeizel AE, Rácz J. Evaluation of drug intake during pregnancy in the Hungarian Case-Control Surveillance of Congenital Anomalies. Teratology 1990; 42: 505–512.PubMedCrossRefGoogle Scholar
  26. XXVI.
    Czeizel A. Drug exposure in pregnant women. Lupus 2004; 13: 740–745.PubMedCrossRefGoogle Scholar
  27. XXVII.
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  28. XXVIII.
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  29. XXIX.
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  30. XXX.
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  31. XXXI.
    Medveczky E, Puho E, Czeizel A. An evaluation of maternal illnesses in the origin of neural-tube defects. Arch Gynecol Obstet 2004; 270: 244–251.PubMedCrossRefGoogle Scholar
  32. XXXII.
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  33. XXXIII.
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  34. XXXIV.
    Czeizel AE, Tusnády G. An epidemiological study of cleft lip with or without cleft palate and posterior cleft palate in Hungary. Hum Hered 1971; 21: 17–38.PubMedCrossRefGoogle Scholar
  35. XXXV.
    Czeizel AE, Tusnády G. A family study on cleft lip with or without cleft palate and posterior cleft palate in Hungary. Hum Hered 1972; 22: 405–416.PubMedCrossRefGoogle Scholar
  36. XXXVI.
    Sárközi A, Wyszynski DF, Czeizel A. Oral clefts with associated anomalies: findings in the Hungarian Congenital Abnormality Registry. BMC Oral Health 2005; 5: 4–18.PubMedCrossRefGoogle Scholar
  37. XXXVII.
    Wyszinsky DE, Sárközy A, Vargha P, Czeizel A. Birth weight and gestational age of newborns with cleft lip with or without cleft palate and with isolated cleft palate. J Clin Pediat Dent 2003; 27: 185–190.Google Scholar
  38. XXXVIII.
    Czeizel AE, Sárközy A, Wyszinsky D. Protective effect of hyperemesis gravidarum for non-syndromic oral cleft. Obstet Gynecol 2003; 101: 737–744.PubMedCrossRefGoogle Scholar
  39. XXXIX.
    Wyszynski DF, Sárközi A, Czeizel A. Oral clefts with associated anomalies: methodological issues. Cleft Palate-Craniofacial J 2006; 43: 1–6.CrossRefGoogle Scholar
  40. XL.
    Métneki J, Puho E, Czeizel A. Maternal disease and isolated orofacial clefts in Hungary. Birth Defects Res A 2005; 73: 617–623.CrossRefGoogle Scholar
  41. XLI.
    Puho HE, Métneki J, Czeizel A. Drug treatment during pregnancy and isolated orofacial clefts in Hungary. Cleft Palate-Craniofacial J 2007; 44: 194–202.CrossRefGoogle Scholar
  42. XLII.
    Puho E, Métneki J, Czeizel A. Maternal employment status and isolated orofacial clefts in Hungary. Cent Eur J Publ Health 2005; 13: 144–148.CrossRefGoogle Scholar
  43. XLIII.
    Szendrey T, Danyi G, Czeizel A. Etiological study on isolated esophageal atresia. Hum Genet 1985; 70: 51–58.PubMedCrossRefGoogle Scholar
  44. XLIV.
    Czeizel A. Birthweight distribution in congenital pyloric stenosis. Arch Dis Child 1972; 47: 978–980.PubMedCrossRefGoogle Scholar
  45. XLV.
    Czeizel A. Congenital hypertrophic pyloric stenosis. In: Czeizel AE, Tusnady G. Aetiological Studies of Isolated Common Congenital Abnormalities in Hungary. Akadémiai Kiadó, Budapest, 1984. pp. 197–120.Google Scholar
  46. XLVI.
    Czeizel AE, Toth J, Czvenits E. Increased birth prevalence of isolated hypospadias in Hungary. Acta Paediatr Hung 1986; 27: 329–337.PubMedGoogle Scholar
  47. XLVII.
    Czeizel AE, Toth J, Erödi E. Aetiological study of hypospadias in Hungary. Hum Hered 1979; 29: 166–171.PubMedCrossRefGoogle Scholar
  48. XLVIII.
    Czeizel AE, Toth J. A correlation between the birth prevalence of isolated hypospadias and parental subfertility. Teratology 1990; 41: 167–172.CrossRefGoogle Scholar
  49. XLIX.
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  50. L.
    Czeizel AE, Erődi É, Toth J. An epidemiological study on undescended testis. J Urol 1981; 126: 524–527.PubMedGoogle Scholar
  51. LI.
    Czeizel AE, Erődi É, Toth J. Genetics of undescended testis. J Urol 1981; 126: 528–529.PubMedGoogle Scholar
  52. LII.
    Czeizel AE, Vitéz M. Etiological study of omphalocele. Hum Genet 1981; 58: 390–395.PubMedCrossRefGoogle Scholar
  53. LIII.
    Abdel-Salam GMH, Vogt G, Halász A, Czeizel A. Microcephaly with normal intelligence and chorioretinopathy. Ophthal Genet 1999; 20: 259–264.PubMedCrossRefGoogle Scholar
  54. LIV.
    Czeizel AE, Abdel-Salam GMH. A case-control etiologic study of microcephaly. Epidemiology 2000; 11: 1–5.CrossRefGoogle Scholar
  55. LV.
    Abdel-Salam GMH, Svékus A, Pelle Z. Microcephaly, microphthalmia, congenital cataract, with calcification of the basal ganglia: MCA/MR syndrome. Genet Counsel 2000; 4: 391–397.Google Scholar
  56. LVI.
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  57. LVII.
    Abdel-Salam GMH, Halász AA, Czeizel A. Association of epilepsy with different groups of microcephaly. Develop Med Child Neurol 2000; 42: 760–767.PubMedCrossRefGoogle Scholar
  58. LVIII.
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  59. LIX.
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  60. LX.
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  61. LXI.
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  62. LXII.
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  63. LXIII.
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  64. LXIV.
    Puhó HE, Vogt G, Czeizel A. Maternal demographic and socioeconomic characteristics of live-born infants with isolated ocular congenital abnormalites. Ophthal Epid 2008; 15: 257–263.CrossRefGoogle Scholar
  65. LXV.
    Czeizel AE, Kamarás J, Balogh Ö, Szentpéteri J. Incidence of congenital heart defects in Budapest. Acta Paediatr Acad Sci Hung 1972; 13: 191–202.PubMedGoogle Scholar
  66. LXVI.
    Mészáros M, Nagy A, Czeizel A. Incidence of congenital heart disease in Hungary. Hum Hered 1975; 25: 513–519.PubMedCrossRefGoogle Scholar
  67. LXVII.
    Mészáros M, Czeizel A. Point prevalence at birth of ventricular septal defect in Hungary. Acta Paediatr Acad Sci Hung 1978; 19: 51–54.PubMedGoogle Scholar
  68. LXVIII.
    Czeizel AE, Mészáros M. Two family studies of children with ventricular septal defects. Eur J Paediatr 1981; 136: 81–85.CrossRefGoogle Scholar
  69. LXIX.
    Mészáros M, Czeizel A. ECG-conduction disturbance in the first-degree relatives of children with ventricular septal defect. Clin Genet 1981; 19: 298–301.PubMedCrossRefGoogle Scholar
  70. LXX.
    Czeizel AE, Pornoi A, Péterffy E, Tarczal E. Study of children of parents operated on for congenital cardiovascular malformation. Br Heart J 1982; 47: 290–293.PubMedCrossRefGoogle Scholar
  71. LXXI.
    Bellyei Á, Czeizel A. A higher incidence of congenital structural talipes equinovarus in gypsies. Hum Hered 1983; 33: 58–59.PubMedCrossRefGoogle Scholar
  72. LXXII.
    Czeizel AE, Bellyei Á, Kránicz J, Mocsai L, Tasnády G. Confirmation of multifactorial threshold model for congenital structural talipes equinovarus. J Med Genet 1981; 19: 99–100.CrossRefGoogle Scholar
  73. LXXIII.
    Czeizel AE, Evans JA, Kodaj I, Lenz W. Congenital Limb Deficiencies in Hungary. Genetic and Teratologic Epidemiological Studies. Akadémiai Kiadó, Budapest, 1994.Google Scholar
  74. LXXIV.
    Czeizel AE, Kodaj I, Lenz W. Smoking during pregnancy and congenital limb deficiency. Br Med J 1994; 308: 1473–1476.CrossRefGoogle Scholar
  75. LXXV.
    Czeizel AE, Kovács M. A family study of congenital diaphragmatic defects. Am J Med Genet 1985; 21: 105–115.PubMedCrossRefGoogle Scholar
  76. LXXVI.
    Fraser FC, Czeizel AE, Hanson C. Increased frequency of neural tube defects in sibs of children with other malformations. Lancet 1982; 2: 144–145.PubMedCrossRefGoogle Scholar
  77. LXXVII.
    Puho HE, Czeizel AE, Ács N, Bánhidy F. Birth outcomes of cases with unclassified multiple congenital abnormalities and pregnancy complicationbs in their mothers depending on the number of component defects. Population-based case-control study. Cong Anom (Kyoto) 2006; 48: 126–136.CrossRefGoogle Scholar
  78. LXXVIII.
    Rockenbauer M, Olsen J, Czeizel AE, Pedersen L, Sorensen HT, EuroMAP group et al. Recall bias in a case-control study on the use of medicine during pregnancy. Epidemiology 2001; 12: 401–406.CrossRefGoogle Scholar
  79. LXXIX.
    Czeizel A. The first trimester concept is outdated. Cong Anom (Kyoto) 2001; 41: 204.CrossRefGoogle Scholar
  80. LXXX.
    Czeizel AE, Puho HE, Ács N, Bánhidy F. The use of specified critical periods of different congenital abnormalities instead of the first trimester concept. Birth Defects Res A 2008; 82: 139–146.CrossRefGoogle Scholar
  81. LXXXI.
    Czeizel A. Specified critical period of different congenital abnormalities: a new approach for human teratology. Cong Anom (Kyoto) 2008; 48: 103–109.CrossRefGoogle Scholar
  82. LXXXII.
    Gönczi L, Czeizel A. Integrating smoking cessation into periconceptional care. Tobacco Control 1996; 5: 160.PubMedCrossRefGoogle Scholar
  83. LXXXIII.
    Christian MS, Czeizel A. Introduction and history of the Hungarian project for monitoring suicide attempts in pregnant women. Toxic Indust Health 2008. 24: 5–9.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Nándor Ács
    • 1
  • Ferenc G. Bánhidy
    • 1
  • Andrew E. Czeizel
    • 2
  1. 1.Second Department of Obstetrics and GynecologySemmelweis UniversityBudapestHungary
  2. 2.Foundation of the Community Control of Hereditary DiseasesBudapestHungary

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