Near Term Prospects for Broad Spectrum Amelioration of Cancer

  • Zheng CuiEmail author


If the impact of aging on cancer is to diminish an immune-based surveillance activity that naturally exists at a high level in young healthy humans, the solution to the problem of cancer could be to simply replenish such a lost activity in cancer patients with functionally validated agents that carry such an activity. Studies in my laboratory have shown that a profound cancer-killing activity (CKA) is present, surprisingly, in the previously overlooked granulocyte fraction of the innate cellular immune system of cancer-resistant mice. Granulocytes with high levels of CKA from cancer-resistant donor mice can be transferred into non-resistant recipients with advanced malignancy to effectively eradicate cancers. Human granulocytes also possess CKA, and CKA in both mouse and human granulocytes declines with age, consistent with the age-related increase in cancer incidence in both species. Furthermore, human CKA activity is low in cancer patients, and human cancer remissions have been associated with conditions that augment granulocyte function. Allogeneic granulocyte transfusion in humans is a safe, approved, and long-established procedure. Therefore, it is possible that transfusion of high CKA granulocytes in a human setting could be a highly effective and non-toxic therapy for human cancers, and a clinical trial of this concept is now beginning.


Cancer Cell S180 Cell Live Cancer Cell Cancer Surveillance Kill Cancer Cell 
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© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Section of Tumor Biology, Department of PathologyWake Forest University School of MedicineWinston-SalemUSA

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