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Repairing Extracellular Aging and Glycation

  • John D. Furber
Chapter

Abstract

Accumulating extracellular molecular modifications play major roles in the etiologies of age-associated physical declines and illnesses. The most important changes are caused by glycation, lipoxidation, cross-linking, and cleavage of the long-lasting extracellular structural proteins (LESPs): collagen, elastin, fibronectin, and laminin. A series of reactions results in several stable structures referred to as “advanced glycation endproducts” (AGEs) and “advanced lipoxidation endproducts” (ALEs). LESP modifications contribute to debilitation in several ways: stiffening and weakening tissues, inciting inflammatory damage, and creating an unhealthy environment for the body’s cells. Some amelioration and postponement of LESP aging can be achieved through dietary composition choices, fasting or calorie restriction, and ingesting foods, herbs, or substances that inhibit glycation or lipoxidation. Exercise and crosslink-breaking substances can repair some damage, thus producing partial rejuvenation. Proposals have been made to look for additional crosslink breakers and deglycators to destroy the full range of AGEs. This author anticipates that repair and rejuvenation of a wide range of extracellular aging and damage may be achieved by stimulating fibroblast-lineage cells to more rapidly turn over and regenerate the extracellular matrix.

Keywords

Diastolic Heart Failure Amadori Product Extracellular Aging Crosslink Breaker Rage Signaling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

I would like to thank George M. Martin, David A. Spiegel, Steven G. Clarke, Ulf T. Brunk, Duncan MacLaren, and especially my editor, Gregory M. Fahy, for their careful reading of earlier drafts or portions of this chapter, and for their helpful comments.

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© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Legendary PharmaceuticalsGainesvilleUSA

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