Suppressive Effect of ERW on Lipid Peroxidation and Plasma Triglyceride Level
Electrolyzed reduced water (ERW) containing hydrogen molecules and Pt nanoparticles is expected as a new antioxidant. Thiobarbituric acid reactive substances (TBARS) assay revealed that ERW had an inhibitory effect on the oxidation of low-density lipoproteins (LDL). In addition, ERW significantly suppressed LDL oxidation in the medium cultured J.774.A1 macrophage like cells. ERW inhibited Cu2+ ion-catalyzed oxidation of LDL ex vivo. ERW lowered lipid peroxide level in blood red cells and plasma triglyceride in rats fed a basal diet containing 2% cholesterol. These results suggest that ERW has anti-LDL oxidation and anti-hyperlipidemia effects.
KeywordsElectrolyzed reduced water Hyperlipidemia LDL Oxidation
- 1.Ye J., Li Y.-P., Hamsaki T., Nakamichi N., Komatsu T., Kashiwagi T., Teruya K., Nishikawa R., Kawahara T., Osada K., Toh K., Abe M., Tian H., Kabayama S., Otsubo K., Morisawa S., Katakura Y., and Shirahata S. (2008) Inhibitory effect of electrolyzed reduced water on tumor angiogenesis. Biol. Pharm. Bull. 31: 19–26.CrossRefPubMedGoogle Scholar
- 2.Ihm S.H., Yoo H.J., Park S.W., and Ihm J. (1999) Effect of aminoguanidine on lipid peroxidation in streptozotocin-induced diabetic rats. Metabolism 48: 1141–1145.Google Scholar