Role of Ubiquitination Promoted During Restimulation in the Induction of T Cell Anergy
Recent studies have demonstrated that some E3 ubiquitin ligases were upregulated in anergic T cells, and suggested that the ubiquitination and degradation of intracellular proteins are involved in the T cell anergy. We examined in this study the kinetics of the ubiquitination in the induction of anergy. Ubiquitinated proteins in the anergic cells remarkably increased after the restimulation. Our results suggest that degradation of specific proteins would occur after the restimulation but not during the induction.
KeywordsFood Allergy Intracellular Protein Ubiquitinated Protein Immunological Tolerance Cell Anergy
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