Role of Ubiquitination Promoted During Restimulation in the Induction of T Cell Anergy

  • Yohei Mizuguchi
  • Ai Yamamoto
  • Makoto Hattori
  • Tadashi Yoshida
Conference paper
Part of the Animal Cell Technology: Basic & Applied Aspects book series (ANICELLTECH, volume 16)


Recent studies have demonstrated that some E3 ubiquitin ligases were upregulated in anergic T cells, and suggested that the ubiquitination and degradation of intracellular proteins are involved in the T cell anergy. We examined in this study the kinetics of the ubiquitination in the induction of anergy. Ubiquitinated proteins in the anergic cells remarkably increased after the restimulation. Our results suggest that degradation of specific proteins would occur after the restimulation but not during the induction.


Food Allergy Intracellular Protein Ubiquitinated Protein Immunological Tolerance Cell Anergy 
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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Yohei Mizuguchi
    • 1
  • Ai Yamamoto
    • 1
  • Makoto Hattori
    • 1
  • Tadashi Yoshida
    • 1
  1. 1.Department of Applied Biological ScienceTokyo University of Agriculture and TechnologyFuchuJapan

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