Bifunctional Acid-Base Catalysis

  • Petri M. Pihko
  • Hasibur Rahaman


Acid-base catalysis with bifunctional catalysts is a very prominent catalytic strategy in both small-molecule organocatalysts as well as enzyme catalysis. In both worlds, small-molecule catalysts and enzymatic catalysis, a variety of different general acids or hydrogen bond donors are used. In this chapter, important parallels between small molecule catalysts and enzymes are discussed, and a comparison is also made to the emerging field of frustrated Lewis pair catalysis.


Hydrogen Bond Donor Bifunctional Catalyst Oxyanion Hole Tetrahedral Intermediate Conjugate Addition 
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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of JyväskyläJyväskyläFinland

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