Abstract
This chapter discusses the various modalities of photomedicine, an interdisciplinary branch of medicine that involves the study and application of light with respect to health and disease. The following main concepts are covered: Photodynamic Therapy (PDT) for the treatment of cancer, PDT for bacterial infections, vascular PDT, photochemical internalisation, photochemical tissue bonding and the use of lasers in medicine.
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References
The Nobel Prize in Physiology or Medicine 1903. http://nobelprize.org/nobel_prizes/medicine/laureates/1903/index.html
Raab C (1900) Ber die wirkung fluoreszierender stoffe auf infu-soria. Z Biol 39:524–546
Tappeiner H, Jesionek H (1903) Therapeutische versuche mit fluo-reszierenden stoffen. Munch Med Wschr 50:2042–2044
Rajakumar K (2003) Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective. Pediatrics 112:e132–e135
Cremer RJ, Perryman PW, Richards DH (1958) Influence of light on the hyper-bilirubinaemia of infants. Lancet 1:1094
McDonagh AF, Lightner DA, Woolridge A (1979) Geometric isomerization of bilirubin-IX and its dimethyl ester. J Chem Soc Chem Commun 3:110
Dolmans DEJGJ, Fukumura D, Jain RK (2003) Photodynamic therapy for cancer. Nat Rev Cancer 3:380–387
Wilson BC, Patterson MS (2008) The physics, biophysics, and technology of photodynamic therapy. Phys Med Biol 53:R61–R109
Advances in photodynamic therapy: basic, translational and clinical (2008) Hamblin MR, Mróz P (eds), Artech House, London
Photodynamic therapy methods and protocols; series: methods in molecular biology (2010) In: Gomer CJ (ed), vol. 635. A product of Humana press, p 294
Wilson BC, Jeeves WP, Lowe DM, Adam G (1984) Light propagation in animal tissues in the wavelength range 375–825 nanometers. Progr Clin Biol Res 170:115–132
Ritz J-P, Roggan A, Isbert C, Müller G, Buhr HJ, Germer CT (2001) Optical properties of native and coagulated porcine liver tissue between 400 and 2400 nm. Lasers Surg Med 29:205–212
Wilkinson F, Helman WP, Ross AB (1995) Quantum yields for the photosensitized forma-tion of the lowest electronically excited singlet state of molecular oxygen in solution. J Phys Chem Ref Data 24:663
Hudson H, Boyle RW (2004) Strategies for selective delivery of photodynamic sensitisers to biological targets. J Porphyrins Phthalocyanines 8:954–975
Sharmon WM, van Lier JE, Allen CM (2004) Targeted photodynamic therapy via receptor mediated delivery systems. Adv Drug Deliv Rev 56:53–76
Hongcharu W, Taylor CR, Chang Y et al (2000) Topical ALA-photodynamic therapy for the treatment of acne vulgaris. J Investigative Dermatol 115:183–192
Peng Q, Warloe T, Berg K et al (1997) 5-Aminolevulinic acid-based photodynamic therapy—clinical research and future challenges. Cancer 79:2282–2308
Egorov SY, Kamalov VF, Koroteev NI et al (1989) The lifetime of singlet oxygen. Chem Phys Lett 163:421–424
Chen B, Pogue BW, Hoopes PJ, Hasan T (2006) Vascular and cellular targeting for photo-dynamic therapy. Critical Rev Eukariotic Gene Express 16:279–305
Arnold J, Kilmartin D, Olson J et al (2001) Verteporfin therapy of subfoveal choroidal ne-ovascularization in age-related macular degeneration: Two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization—verteporfin in photodynamic therapy report 2. Am J Ophthalmol 131:541–560
Arnold J, Kilmartin D, Olson J et al (2001) Photodynamic therapy of subfoveal choroidal neovascularization in pathologic myopia with verteporfin—1-year results of a randomized clinical trial—VIP report no. 1. Ophthalmology 108:841–852
Hamblin MR, Hasan T (2004) Photodynamic therapy: a new antimicrobial approach to infectious disease? Photochem Photobiol Sci 3:436–450
Jori G, Fabris C, Soncin M et al (2006) Photodynamic therapy in the treatment of microbial infections: Basic principles and perspective applications. Lasers Surg Med 38:468–481
Phillips D (1997) Chemical mechanisms in photodynamic therapy with phthalocyanines. Prog React Kinetics 22:175–300
Berg K, Selbo PK, Prasmickaite L et al (1999) Photochemical internalization: A novel technology for delivery of macromolecules into cytosol. Cancer Res 59:1180–1183
Hogset A, Prasmickaite L, Selbo PK et al (2004) Photochemical internalisation in drug and gene delivery. Adv Drug Delivery Rev 56:95–115
Kamegaya Y, Farinelli WA, Echague AVV et al (2005) Evaluation of photochemical tissue bonding for closure of skin incisions and excisions. Lasers Surg Med 37:264–270
Tsao S, Yao M, Henry FP et al (2010) A phase I/II trial of photoactivated tissue bonding (“nanosuturing”) for excisional wound closure. J Investig Dermatol 130:S42–S42
Bhawalkar JD, Kumar ND, Zhao CF, Prasad PN (1997) Two-photon photodynamic therapy. J Clin Laser Med Surg 15:201
Fisher WG, Partridge WP, Dees C, Wachter EA (1997) Simultaneous two-photon activation of type-I photodynamic therapy agents. Photochem Photobiol 66:141–155
Dy JT, Ogawa K, Satake A, Ishizumi A, Kobuke Y (2007) Water-soluble self-assembled butadiyne-bridged bisporphyrin: a potential two-photon-absorbing photosensitizer for photodynamic therapy. Chem Eur J 13:3491–3500
Balaz M, Collins HA, Dahlstedt E, Anderson HL (2009) Synthesis of hydrophilic conjugated porphyrin dimers for one-photon and two-photon photodynamic therapy at NIR wave-lengths. Org Biomol Chem 7:874–888
Arnbjerg J, Jimenez-Banzo A, Paterson MJ et al (2007) Two-photon ab-sorption in tetra-phenylporphycenes: are porphycenes better candidates than porphyrins for providing optimal optical properties for two-photon photodynamic therapy? J Am Chem Soc 129:5188–5199
Collins HA, Khurana M, Moriyama EH et al (2008) Blood-vessel closure using photosensitizers engineered for two-photon excitation. Nat Photonics 7:420–424
Yanik MF, Cinar H, Cinar HN et al (2004) Functional regeneration after laser axotomy. Nature 432:882
Acknowledgments
The current work of MKK in the areas of biological imaging and photomedicine is supported by the UK’s Engineering and Physical Sciences Research Council (EPSRC) in the form of the Career Acceleration Fellowship (EP/E038980/1) and this support is gratefully acknowledged.
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Kuimova, M.K., Phillips, D. (2013). Photomedicine. In: Evans, R., Douglas, P., Burrow, H. (eds) Applied Photochemistry. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3830-2_9
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DOI: https://doi.org/10.1007/978-90-481-3830-2_9
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