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Carcinogenesis of Lung Cancer

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Mechanisms of Oncogenesis

Part of the book series: Cancer Growth and Progression ((CAGP,volume 12))

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Abstract

Lung cancer is the most common cause of mortality worldwide. It is highly associated with tobacco smoking and toxins from tobacco smoke are known to increase the risk of lung cancer, in particular adenocarcinoma. Adenocarcinoma of the lung is a stepwise accumulation of genetic abnormalities with morphological differences seen in the cytology and histology of atypical alveolar hyperplasia, bronchioloalveolar carcinoma and invasive adenocarcinoma. Multiple molecular pathways, in example loss of heterozygosity of tumor suppressor genes, chromosome breakage, deletions, nucleotide changes, amplification and hypermethylation are found in the stepwise progression of lung cancer. The recognition of proliferation markers and molecular pathways in the stepwise progression of lung cancer may allow for earlier detection and better therapy response for patients with pre-neoplastic or frank lung cancer.

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Author information

Authors and Affiliations

  1. Anatomic and Clinical Pathology, University of South Florida, Tampa, FL, USA

    Jeffrey Aufman

  2. University of South Florida, Tampa, FL, USA

    Farah Khalil

  3. H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

    Farah Khalil

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  1. Jeffrey Aufman
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  2. Farah Khalil
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Corresponding author

Correspondence to Jeffrey Aufman .

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Editors and Affiliations

  1. Research Institute, H. Lee Moffitt Cancer Center &, Magnolia Drive 12902, Tampa, 33612, USA

    Domenico Coppola

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Aufman, J., Khalil, F. (2010). Carcinogenesis of Lung Cancer. In: Coppola, D. (eds) Mechanisms of Oncogenesis. Cancer Growth and Progression, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3725-1_14

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  • DOI: https://doi.org/10.1007/978-90-481-3725-1_14

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-3724-4

  • Online ISBN: 978-90-481-3725-1

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