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Carcinogenesis of Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

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Mechanisms of Oncogenesis

Part of the book series: Cancer Growth and Progression ((CAGP,volume 12))

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Abstract

Head and neck squamous cell carcinoma is the most common head and neck malignant tumor. Much progress has been made in studying its carcinogenesis, though it is still an open question. Human papillomavirus (HPV) has been shown to play a possible role in the carcinogenesis of head and neck squamous cell carcinoma. Similar to its role in human uterus cervical cancer, HPV has been identified in association with head and neck squamous cell carcinoma, esp. those arising from tonsil. Based on its correlation with squamous cell carcinoma, HPV is divided into two groups: high and low risk groups. HPV 16 in the high risk group is most common variant associated with head and neck squamous cell carcinoma. Two HPV genes (E6 and E7) are found to be necessary and sufficient to immortalize human keratinocytes. The E6 and E7 proteins bind to p53 and RB1 respectively and accelerate the degradation of these tumor suppressor gene products, which may partially contribute to the carcinogenesis of head and neck squamous cell carcinoma. HPV can be detected by different methods on different type of specimens. The methods include immunohistochemistry, in situ hybridization, PCR, and signal amplification. Recently, an invader assay receives FDA approval for HPV in uterus cervical cancer. The method might also be used for head and neck squamous cell carcinoma after technical and clinical validation.

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  1. Department of Anatomic Pathology, Moffitt Cancer and Research Center, Tampa, FL, USA

    Dahui Qin

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  1. Research Institute, H. Lee Moffitt Cancer Center &, Magnolia Drive 12902, Tampa, 33612, USA

    Domenico Coppola

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Qin, D. (2010). Carcinogenesis of Human Papillomavirus in Head and Neck Squamous Cell Carcinoma. In: Coppola, D. (eds) Mechanisms of Oncogenesis. Cancer Growth and Progression, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3725-1_12

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