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Role of HU in Regulation of gal Promoters

  • Chapter
Bacterial Chromatin

Abstract

HU is one of the histone-like DNA binding proteins, which are involved in maintaining the nucleoid structure in bacteria. HU has also been shown to ­participate in transcriptional regulation of specific promoters. In this chapter, we provide an overview of the mechanism of HU action in the transcriptional ­regulation of the two promoters of the gal operon in E. coli by providing results of genetic, biophysical and biochemical experiments both in vivo and in vitro.

The online version of the Erratum chapter can be found at 10.1007/978-90-481-3473-1_19

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Acknowledgements

Much of the work described in this chapter is from the authors’ laboratory. We gratefully acknowledge the contributions of many of our past and present colleagues and collaborators too numerous to list. We are supported by the Intramural Research Program of the National Institutes of Health, the National Cancer Institute, the Center for Cancer Research. We thank Dr. Dhruba Chattoraj for suggestions and critical reading of the manuscript.

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  1. Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD, 20892, USA

    Dale E. A. Lewis, Sang Jun Lee & Sankar Adhya

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  1. Dale E. A. Lewis
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  2. Sang Jun Lee
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  3. Sankar Adhya
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Correspondence to Sankar Adhya .

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Editors and Affiliations

  1. Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands

    Remus T. Dame (Faculty of Mathematics and Natural Sciences) (Faculty of Mathematics and Natural Sciences)

  2. Division of Physics and Astronomy Section Physics of Complex Systems, VU University Amsterdam, De Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands

    Remus T. Dame (Faculty of Mathematics and Natural Sciences) (Faculty of Mathematics and Natural Sciences)

  3. Department of Microbiology School of Genetics and Microbiology, University of Dublin Trinity College, Dublin 2, Ireland

    Charles J. Dorman

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Lewis, D.E.A., Lee, S.J., Adhya, S. (2010). Role of HU in Regulation of gal Promoters. In: Dame, R.T., Dorman, C.J. (eds) Bacterial Chromatin. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3473-1_17

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