Computational Homogenization of Polymeric Nanofiber Scaffolds and Biological Cells

  • J. N. ReddyEmail author
  • V. U. Unnikrishnan
  • G. U. Unnikrishnan
Part of the Solid Mechanics and Its Applications book series (SMIA, volume 168)


An understanding of the structure–property relationship is essential for the estimation of mechanical properties of nano-materials like polymeric nanofibers and biological materials like cells and tissues. The properties of these structures are closely related to the internal molecular structure and therefore a multiscale based mathematical modeling is required for the determination of its macroscopic properties. In this investigation, we present multiscale mathematical models to estimate the mechanical properties of polymeric nanofibers from the basic building blocks to the macroscale nanofibrous structures and also study the homogenization of biological cells considering the microcellular constituents.Theoretical analysis of polymeric nanofibers based scaffolds are necessary towards designing novel bio-medical applications, while through homogenization of biological cells new diagnostic tools based on mechanical properties could be developed.


Actin Filament Representative Volume Element Stress Fiber Effective Modulus Nanofibrous Scaffold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors gratefully acknowledge the support of this research through Oscar S. Wyatt Endowed Chair funds at the Texas A&M University.


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • J. N. Reddy
    • 1
    Email author
  • V. U. Unnikrishnan
  • G. U. Unnikrishnan
  1. 1.Advanced Computational Mechanics Laboratory, Department of Mechanical EngineeringTexas A&M UniversityCollege StationUSA

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