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Hypoxia-Inducible Factors and Adenosine Signaling in Vascular Growth

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Extracellular ATP and Adenosine as Regulators of Endothelial Cell Function

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Abstract

Low oxygen environment or hypoxia is conducive towards vascular growth and endothelial proliferation. Therefore it is an essential element in both disease and development. Hypoxia stabilizes the hypoxia-inducible transcription factors -1α and -2α and also increases adenosine levels thereby activating the adenosine receptor signaling pathways. While these pathways have been described independently to a greater extent, increasing evidence suggests that there is significant crosstalk. Here we will summarize the contributions and interdependence of hypoxia-inducible transcription factors and the adenosine receptor pathways in vascular growth.

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  1. Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206, USA

    Aftab Ahmad, Carl W. White & Shama Ahmad

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  1. Aftab Ahmad
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Correspondence to Aftab Ahmad .

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  1. Dept. Pediatrics, Pediatric Clinical Services, University of Colorado, Denver, East 19th Avenue 12700, Aurora, 80045, USA

    Evgenia Gerasimovskaya

  2. Beth Israel Deaconess Medical Center, Harvard Medical School, Brookline Ave. 99, Boston, 02215, USA

    Elzbieta Kaczmarek

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Ahmad, A., White, C.W., Ahmad, S. (2010). Hypoxia-Inducible Factors and Adenosine Signaling in Vascular Growth. In: Gerasimovskaya, E., Kaczmarek, E. (eds) Extracellular ATP and Adenosine as Regulators of Endothelial Cell Function. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3435-9_7

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