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Heat Shock Proteins and Whole Body Physiology pp 19–29Cite as

Role of Heat Shock Proteins in Obesity and Type 2 Diabetes

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Part of the book series: Heat Shock Proteins ((HESP,volume 5))

Abstract

Heat shock proteins (HSP) play an important role in human health and physiology and are known to function intracellularly as cytoprotection proteins by protecting cells against a wide variety of stressors, and extracellularly as chaperokines by stimulating the synthesis of pro-inflammatory cytokines, chemokines, and upregulates co-stimulatory molecule expression on antigen presenting cells, and enhancing natural killer (NK) cell-mediated migration and general anti-tumor responses. Obesity is known to be associated with raised serum inflammatory markers suggesting a state of heightened immune activation. The recent findings that antibody titers to several HSP are elevated in dyslipidaemic patients and individuals with established vascular disease, and that patients with Type 2 diabetes have reduced gene expression of Hsp72 which correlates with reduced insulin sensitivity point to an important role for HSP in obesity and Type 2 diabetes. This chapter briefly reviews recent advances in our understanding of the role of Hsp70 in obesity and Type 2 diabetes

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Abbreviations

BMI:

body mass index

CDC:

center for disease control

CRP:

C-reactive protein

CVD:

cardiovascular disease

FBG:

fasting blood glucose

FFA:

free fatty acids

GRP:

glucose regulated proteins

HSF:

heat shock factor

Hsp:

heat shock proteins

hsp :

heat shock protein gene

HSP:

heat shock protein family

IGF-1:

insulin growth factor-1

IL:

interleukin

JNK:

c-jun N-terminal kinase

MAPK:

mitogen activated protein kinases

MCP-1:

monocyte chemotactic protein-1

NK:

natural killer

TNF-α:

tumor necrosis factor-alpha

WHO:

World Health Organization

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Acknowledgements

The authors thank the Proteomics Core Facility at Scott & White Hospital and Clinic. This work was supported in part by the National Institutes of Health grant RO1CA91889, institutional support from Scott & White Memorial Hospital and Clinic, Texas A&M University System Health Science Center College of Medicine, the Central Texas Veterans Health Administration and an Endowment from the Cain Foundation (to A. A).

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Authors and Affiliations

  1. Division of Investigative Pathology, The Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and Clinic, Temple, TX, USA

    Punit Kaur, John F. Greene Jr & Alexzander Asea

  2. Department of Family & Community Medicine, The Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and Clinic, Temple, TX, USA

    Michael D. Reis, Glen R. Couchman & Samuel N. Forjuoh

  3. Division of Investigative Pathology, The Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and Clinic, 1901 South First Street, Building 205, Room 1R36, Temple, TX, 76508, USA

    Alexzander Asea

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  1. Punit Kaur
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Correspondence to Alexzander Asea .

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Editors and Affiliations

  1. College of Medicine, Texas A & M University System, South 1st St. 1901, Temple, 76508, U.S.A.

    Alexzander A. A. Asea

  2. Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Koebenhavn, 2100, Denmark

    Bente K. Pedersen

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Kaur, P., Reis, M.D., Couchman, G.R., Forjuoh, S.N., Greene, J.F., Asea, A. (2010). Role of Heat Shock Proteins in Obesity and Type 2 Diabetes. In: Asea, A., Pedersen, B. (eds) Heat Shock Proteins and Whole Body Physiology. Heat Shock Proteins, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3381-9_2

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