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Heat Shock Proteins and Post-Traumatic Stress Disorder

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Heat Shock Proteins and Whole Body Physiology

Part of the book series: Heat Shock Proteins ((HESP,volume 5))

Abstract:

Heat shock proteins (HSPs), a highly conserved family of stress response proteins, play a very important role in traumatic stress associated with Post-traumatic Stress disorder (PTSD), a psychiatric disorder observed in a high number of combat veterans and in others exposed to natural disasters, traffic accidents, terrorist attacks, etc. In this chapter, we will briefly review the expression of HSPs in the central nervous system (CNS) and discuss the underlying molecular mechanisms of HSPs in PTSD. We will also present evidence regarding the possible role of HSPs in glucocorticoid receptor (GR) trafficking and in the regulation of p11, a PTSD-associated protein. Advances in the understanding of the functions of HSPs have reached a point where clinical trials are warranted to determine the role of HSPs in the treatment and diagnosis of PTSD

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Abbreviations

CNS:

central nervous system

GR:

glucocorticoid receptors

GRE:

glucocorticoid response elements

PTSD:

Post-traumatic Stress Disorder

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Acknowledgments

We would like to thank Anna Chen for her help in editing the manuscript and images.

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Authors and Affiliations

  1. Department of Psychiatry, Center for the Study of Traumatic Stress, Uniformed Services, University of the Health Sciences, Bethesda, MD, USA

    Lei Zhang (Assistant Professor), He Li & Robert J. Ursano

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  1. Lei Zhang
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  2. He Li
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  3. Robert J. Ursano
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Correspondence to Lei Zhang .

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Editors and Affiliations

  1. College of Medicine, Texas A & M University System, South 1st St. 1901, Temple, 76508, U.S.A.

    Alexzander A. A. Asea

  2. Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Koebenhavn, 2100, Denmark

    Bente K. Pedersen

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Zhang, L., Li, H., Ursano, R.J. (2010). Heat Shock Proteins and Post-Traumatic Stress Disorder. In: Asea, A., Pedersen, B. (eds) Heat Shock Proteins and Whole Body Physiology. Heat Shock Proteins, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3381-9_11

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