Proposal for Blood-Flow Imaging by Contrast Echo Using Counter-Crossed Beams

  • T. EuraEmail author
  • K. Yoshida
  • Y. Watanabe
  • T. Takayasu
  • K. Nakamura
  • I. Akiyama
Conference paper
Part of the Acoustical Imaging book series (ACIM, volume 30)


We propose a new contrast-echo method using counter-crossed beams of two ultrasonic frequencies as an ultrasound diagnostic for cancer. We call this the Counter-Cross Beam Contrast-Echo (C-CBCE) method. Sum and difference frequency components derived from nonlinear vibration of the contrast agents (microbubbles) driven by dual-frequency ultrasound are used in the C-CBCE method. In this study, we used Sonazoid microbubbles as we attempted to detect the sum frequency component generated by Sonazoid fixed in agar gel. We also measured the in-channel flow velocity of the Sonazoid.


Contrast-echo method Dual-frequency drive Contrast agents Nonlinear vibration Microbubbles Sum frequency component 



This work was supported by KAKENHI (20300181).


  1. 1.
    Akiyama, I., Ohya, A., Saito, S.: Speckle noise reduction by superposing many higher harmonic images. Jpn. J. Appl. Phys. 44, 4631–4636 (2005)ADSCrossRefGoogle Scholar
  2. 2.
    Tanaka, S., Kitamura, T., Fujita, M., Nakanishi, K., Okuda, S.: Color Doppler flow imaging of liver tumors. Am. J. Roentgenol. 154(3), 509–514 (1990)Google Scholar
  3. 3.
    Akiyama, I., Yoshimoto, N., Yoshida, K., Watanabe, Y.: Measurement of secondary waves generated by nonlinear vibration of microbubbles in the crossed beams of two ultrasonic frequencies, nonlinear acoustics-fundamentals and applications. In: Enflo B.O., Hedberg C.M., Kari L. (eds.) AIP Conference Proceedings, New York, USA, pp. 432–435 (2008)Google Scholar
  4. 4.
    Tanaka, S., Hamada, Y., Ioka, T., Sugiyama, T., Akamatsu, I., Takakura, R., Yoshioka, F., Nakaizumi, A., Ishida, T.: Contrast-enhanced multiphase dynamic ultrasonography for the characterization of liver tumors. J. Med. Ultrason. 32(2), 57–63 (2005)CrossRefGoogle Scholar
  5. 5.
    Leighton, T.G.: The Acoustic Bubble. Academic Press, London, pp. 413–424 (1994)Google Scholar
  6. 6.
    Young, F.R.: Cavitation. McGraw-Hill Companies, London, pp. 115–136 (1990)Google Scholar
  7. 7.
    Watanabe, R., Matsumura, M., Chen, C.J., Kaneda, Y., Fujimaki, M.: Characterization of Tumor Imaging with Microbubble-Based Ultrasound Contrast Agent, Sonazoid, in Rabbit Liver. Biol. Pharm. Bull. 28(6), 972–977 (2005)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • T. Eura
    • 1
    Email author
  • K. Yoshida
    • 2
  • Y. Watanabe
    • 2
  • T. Takayasu
    • 3
  • K. Nakamura
    • 3
  • I. Akiyama
    • 4
  1. 1.Faculty of EngineeringDoshisha UniversityKyotoJapan
  2. 2.Faculty of Life and Medical SciencesDoshisha UniversityKyotoJapan
  3. 3.Department of Electrical and Electronic EngineeringTokyo Institute of TechnologyTokyoJapan
  4. 4.Department of Electrical and Electronic EngineeringShonan Institute of TechnologyFujisawaJapan

Personalised recommendations