High Frequency Ultrasound Imaging of Cartilage-Bone Complex

  • Y. Hagiwara
  • Y. Saijo
  • A. Ando
  • K. Kobayashi
  • A. Tanaka
  • N. Hozumi
  • K. Hatori
  • E. Itoi
Conference paper
Part of the Acoustical Imaging book series (ACIM, volume 30)


High frequency ultrasound microscope with central frequency of 100 MHz was developed. The system was capable of (1) conventional C-mode acoustic microscope imaging of thinly sliced tissue, (2) ultrasound impedance imaging of the surface of in vitro thick tissue and (3) 3D ultrasound imaging of inside of the in vitro tissue. In the present study, cylindrical cartilage-bone unit specimens were removed from rat knee joints and evaluated with the equipment. The resolution was enough to visualize the articular cartilage surface morphology and the subchondral bone. Compared with histological sections observed by optical microscope, it can also differentiate the non-calcified zone and calcified zone of the articular cartilage. High frequency ultrasound microscope will provide important information of the structural changes of the articular cartilage.


Ultrasound Articular cartilage Subchondral bone 3-D imaging Ultrasound microscopy Osteoarthritis 


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Y. Hagiwara
    • 1
  • Y. Saijo
    • 2
  • A. Ando
    • 2
  • K. Kobayashi
    • 3
  • A. Tanaka
    • 4
  • N. Hozumi
    • 5
  • K. Hatori
    • 6
  • E. Itoi
    • 6
  1. 1.Department of Orthopaedic SurgeryTohoku University School of MedicineSendaiJapan
  2. 2.Graduate School of Biomedical Engineering, Tohoku UniversitySendaiJapan
  3. 3.Honda Electronics Co. Ltd.ToyohashiJapan
  4. 4.Faculty of Symbiotic Systems ScienceFukushima UniversityFukushimaJapan
  5. 5.Aichi Institute of TechnologyToyotaJapan
  6. 6.Tohoku University Graduate School of DentistrySendaiJapan

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