Skip to main content

Advanced Ovarian Cancer: Prediction of Surgical Outcomes Using Computed Tomography

  • Chapter
  • First Online:
Methods of Cancer Diagnosis, Therapy, and Prognosis

Part of the book series: Methods of Cancer Diagnosis, Therapy and Prognosis ((HAYAT,volume 6))

  • 1623 Accesses

Abstract

The characterization of adnexal masses has been facilitated remarkably by the use of pelvic ultrasound during the last decade. Its ease of use, accessibility, relatively low cost, and the recent introduction of color and duplex scanning has made this modality invaluable. Please see other chapters in this volume for a discussion of the use of ultrasound for differentiating benign from malignant ovarian masses. For patients with advanced ovarian cancer and a known pelvic mass which can be palpated on bimanual exam, however, ultrasonography is rarely helpful other than to confirm the presence of ascites. While magnetic resonance imaging (MRI) provides precise information regarding the location of disease and invasion of tissue planes, such detailed anatomic relationships are generally not clinically relevant for treatment planning in patients with advanced ovarian carcinoma, particularly given the associated costs. This is in contradistinction to cervical cancer, in which MRI has been shown to be sensitive for the detection of parametrial involvement, a parameter which significantly alters the plan of treatment if present (Yu et al. 1998). 18F fluorodeoxyglucose-positron emission tomography (FDG-PET) is highly sensitive for cancerous lesions and may ultimately prove useful for the detection of recurrences, but the cost/benefit ratio is poor for the preoperative evaluation of primary ovarian cancer. Computed tomo­graphy (CT) offers advantages over other techniques: relatively low cost, fast scan times, wide availability, and evaluation of the entire abdominal cavity. Furthermore, the use of intravenous and oral contrast improves visualization of retroperitoneal anatomy (Figure 8.1). For these reasons, CT has become a common diagnostic procedure to assess the extent of disease and plan surgical interventions in patients with advanced ovarian cancer. This chapter addresses the use of CT imaging in this cohort of patients and its potential to predict surgical outcome.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aletti, G.D., Dowdy, S.C., Gostout, B.S., Jones, M.B., Stanhope, C.R., Wilson, T.O., Podratz, K.C., and Cliby, W.A. (2006) Aggressive surgical effort. and improved survival. in advanced-stage ovarian cancer. Obstet. Gynecol. 107:77–85

    Article  PubMed  Google Scholar 

  • Axtell, A.E., Lee, M.H., Bristow, R.E., Dowdy, S.C., Cliby, W.A., Raman, S., Weaver, J.P., Gabbay, M., Ngo, M., Lentz, S., Cass, I., Li, A.J., Karlan, B.Y., and Holschneider, C.H. (2007) Multi-institutional reciprocal validation study of computed tomography predictors of suboptimal primary cytoreduction in patients with advanced ovarian cancer. J. Clin. Oncol. 25:384–389

    Article  PubMed  Google Scholar 

  • Bristow, R.E., Duska, L.R., Lambrou, N.C., Fishman, E.K., O’Neill, M.J., Trimble, E.L., and Montz, F.J. (2000) A model for predicting surgical outcome in patients with advanced ovarian carcinoma using computed tomography. Cancer 89:1532–1540

    Article  PubMed  CAS  Google Scholar 

  • Buist, M.R., Golding, R.P., Burger, C.W., Vermorken, J.B., Kenemans, P., Schutter, E.M., Baak, J.P., Heitbrink, M.A., and Falke, T.H. (1994) Comparative evaluation of diagnostic methods in ovarian carcinoma with emphasis on CT and MRI. Gynecol. Oncol. 52:191–198

    Article  PubMed  CAS  Google Scholar 

  • Chi, D.S., Franklin, C.C., Levine, D.A., Akselrod, F., Sabbatini, P., Jarnagin, W.R., DeMatteo, R., Poynor, E.A., Abu-Rustum, N.R., and Barakat, R.R. (2004) Improved optimal cytoreduction rates for stages IIIC. and IV epithelial. ovarian., fallopian tube., and primary peritoneal cancer: a change in surgical approach. Gynecol. Oncol. 94:650–654

    Article  PubMed  Google Scholar 

  • Choi, H., Choi, S.R., Zhou, R., Kung, H.F., and Chen, I.W. (2004) Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery. Acad. Radiol. 11:996–1004

    Article  PubMed  Google Scholar 

  • Cooper, B.C., Sood, A.K., Davis, C.S., Ritchie, J.M., Sorosky, J.I., Anderson, B., and Buller, R.E. (2002) Preoperative CA 125 levels: an independent prognostic factor for epithelial ovarian cancer. Obstet. Gynecol. 100:59–64

    Article  PubMed  CAS  Google Scholar 

  • Dowdy, S.C., Mullany, S.A., Brandt, K.R., Huppert, B.J., and Cliby, W.A. (2004) The utility of computed tomography scans in predicting suboptimal cytoreductive surgery in women with advanced ovarian carcinoma. Cancer 101:346–352

    Article  PubMed  Google Scholar 

  • Eisenkop, S.M., Friedman, R.L., and Wang, H.J. (1998) Complete cytoreductive surgery is feasible. and maximizes survival. in patients with advanced epithelial ovarian cancer: a prospective study. Gynecol. Oncol. 69:103–108

    Article  PubMed  CAS  Google Scholar 

  • Forstner, R., Hricak, H., Occhipinti, K.A., Powell, C.B., Frankel, S.D., and Stern, J.L. (1995a) Ovarian cancer: staging with CT. and MR imaging. Radiology 197:619–626

    PubMed  CAS  Google Scholar 

  • Forstner, R., Hricak, H., Powell, C.B., Azizi, L., Frankel, S.B., and Stern, J.L. (1995b) Ovarian cancer recurrence: value of MR imaging. Radiology 196:715–720

    PubMed  CAS  Google Scholar 

  • Goldie, J.H., and Coldman, A.J. (1979) A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer. Treat. Rep. 63:1727–1733

    PubMed  CAS  Google Scholar 

  • Griffiths, C.T., Parker, L.M., and Fuller, A.F. Jr (1979) Role of cytoreductive surgical treatment in the management of advanced ovarian cancer. Cancer. Treat. Rep. 63:235–240

    PubMed  CAS  Google Scholar 

  • Heintz, A.P., Hacker, N.F., Berek, J.S., Rose, T.P., Munoz, A.K., and Lagasse, L.D. (1986) Cytoreductive surgery in ovarian carcinoma: feasibility and morbidity. Obstet. Gynecol. 67:783–788

    Article  PubMed  CAS  Google Scholar 

  • HoskinsWJ, McGuire, W.P., Brady, M.F., Homesley, H.D., Creasman, W.T., Berman, M., Ball, H., and Berek, J.S. (1994) The effect of diameter of largest residual disease on survival after primary cytoreductive surgery in patients with suboptimal residual epithelial ovarian carcinoma. Am. J. Obstet. Gynecol. 170(4):974–979; discussion 979–980

    Google Scholar 

  • McGuire, W.P., Hoskins, W.J., Brady, M.F., Kucera, P.R., Partridge, E.E., Look, K.Y., Clarke-Pearson, D.L., and Davidson, M. (1996) Cyclophosphamide and cisplatin versus paclitaxel and cisplatin: a phase III randomized trial in patients with suboptimal stage III/IV ovarian cancer (from the Gynecologic Oncology Group). Semin. Oncol. 23:40–47

    PubMed  CAS  Google Scholar 

  • Memarzadeh, S., Lee, S.B., Berek, J.S., Farias-Eisner R (2003) CA125 levels are a weak predictor of optimal cytoreductive surgery in patients with advanced epithelial ovarian cancer. Int. J. Gynecol. Cancer. 13:120–124

    Article  PubMed  CAS  Google Scholar 

  • Meyer, J.I., Kennedy, A.W., Friedman, R., Ayoub, A., and Zepp, R.C. (1995) Ovarian carcinoma: value of CT in predicting success of debulking surgery. AJR. Am. J. Roentgenol. 165:875–878

    Article  PubMed  CAS  Google Scholar 

  • Nelson, B.E., Rosenfield, A.T., and Schwartz, P.E. (1993) Preoperative abdominopelvic computed tomographic prediction of optimal cytoreduction in epithelial ovarian carcinoma. J. Clin. Oncol. 11:166–172

    PubMed  CAS  Google Scholar 

  • Ozols, R.F., Bundy, B.N., Greer, B.E., Fowler, J.M., Clarke-Pearson, D., Burger, R.A., Mannel, R.S., DeGeest, K., Hartenbach, E.M., and Baergen, R. (2003) Phase III trial of carboplatin. and paclitaxel compared. with cisplatin. and paclitaxel in. patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. J. Clin. Oncol. 21:3194–3200

    Article  PubMed  CAS  Google Scholar 

  • Qayyum, A., Coakley, F.V., Westphalen, A.C., Hricak, H., Okuno, W.T., and Powell, B. (2005) Role of CT. and MR imaging. in predicting optimal cytoreduction of newly diagnosed primary epithelial ovarian cancer. Gynecol. Oncol. 96:301–306

    Article  PubMed  Google Scholar 

  • Ricke, J., Sehouli, J., Hach, C., Hanninen, E.L., Lichtenegger, W., and Felix, R. (2003) Prospective evaluation of contrast-enhanced MRI in the depiction of peritoneal spread in primary or recurrent ovarian cancer. Eur. Radiol. 13:943–949

    Article  PubMed  Google Scholar 

  • Santra, S., Liesenfeld, B., Dutta, D., Chatel, D., Batich, C.D., Tan, W., Moudgil, B.M., and Mericle, R.A. (2005) Folate conjugated fluorescent silica nanoparticles for labeling neoplastic cells. J. Nanosci. Nanotechnol. 5:899–904

    Article  PubMed  CAS  Google Scholar 

  • Schroder, W., Zimny, M., Rudlowski, C., Bull, U., and Rath, W. (1999) The role of 18F-fluoro-deoxyglucose positron emission tomography (18F-FDG PET) in diagnosis of ovarian cancer. Int. J. Gynecol. Cancer. 9:117–122

    Article  PubMed  Google Scholar 

  • Schwartz, P.E., Rutherford, T.J., Chambers, J.T., Kohorn, E.I., and Thiel, R.P. (1999) Neoadjuvant chemotherapy for advanced ovarian cancer: long-term survival. Gynecol. Oncol. 72:93–99

    Article  PubMed  CAS  Google Scholar 

  • Semelka, R.C., Lawrence, P.H., Shoenut, J.P., Heywood, M., Kroeker, M.A., and Lotocki, R. (1993) Primary ovarian cancer: prospective comparison of contrast-enhanced CT and pre-and postcontrast., fat-suppressed MR imaging., with histologic correlation. J. Magn. Reson. Imaging. 3:99–106

    Article  PubMed  CAS  Google Scholar 

  • Skipper HE (1978) Adjuvant chemotherapy. Cancer 41:936–940

    Article  PubMed  CAS  Google Scholar 

  • Stevens, S.K., Hricak, H., and Stern, J.L. (1991) Ovarian lesions: detection and characterization with gadolinium-enhanced MR imaging at 1.5, T. Radiology 181:481–488

    PubMed  CAS  Google Scholar 

  • van der Burg, M.E., van Lent, M., Buyse, M., Kobierska, A., Colombo, N., Favalli, G., Lacave, A.J., Nardi, M., Renard, J., and Pecorelli, S. (1995) The effect of debulking surgery after induction chemotherapy on the prognosis in advanced epithelial ovarian cancer. Gynecological Cancer Cooperative Group of the European Organization for Research. and Treatment of. Cancer. N. Engl. J. Med. 332:629–634

    Article  PubMed  Google Scholar 

  • Yu, K.K., Hricak, H., Subak, L.L., Zaloudek, C.J., and Powell, C.B. (1998) Preoperative staging of cervical carcinoma: phased array coil fast spin-echo versus body coil spin-echo T2-weighted MR imaging. AJR. Am. J. Roentgenol. 171:707–711

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Dowdy, S.C., Cliby, W.A. (2010). Advanced Ovarian Cancer: Prediction of Surgical Outcomes Using Computed Tomography. In: Hayat, M. (eds) Methods of Cancer Diagnosis, Therapy, and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2918-8_8

Download citation

  • DOI: https://doi.org/10.1007/978-90-481-2918-8_8

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-2917-1

  • Online ISBN: 978-90-481-2918-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics