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The calcitonin gene-related peptide family pp 199–233Cite as

Calcitonin Receptor Expression in Embryonic, Foetal and Adult Tissues: Developmental and Pathophysiological Implications

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Abstract

It has been well established that the calcitonin receptor (CTR) mediates the actions of calcitonin in bone homeostatic mechanisms during growth and in adulthood. However, the widespread expression of CTR in embryonic, foetal and adult tissues together with functional studies implicates the activity of CTR in other physiological and pathophysiological events including wound healing, cardiovascular disease and some cancers. The development of high affinity anti-CTR antibodies has helped define the roles of CTR in organogenesis and pathogenesis, and has focused our attention on the roles of precursor cells that express CTR. These CTR-positive cells are featured in foetal development, cardiovascular disease and leukaemia. It is hypothesised that the potential to express CTR is a fundamental property of precursors and progeny of the haematopoietic lineages.

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Abbreviations

AGM:

Aorta-gonado-mesonephros

ALL:

Acute lymphoblastic leukaemia

AM:

Adrenomedullin

AML:

Acute myeloblastic leukaemia

CD34:

Cluster of differentiation antigen 34

CGRP:

Calcitonin gene-related peptide

CLR:

Calcitonin receptor-like receptor

CNS:

Central nervous system

CT:

Calcitonin

hCT:

Rhuman calcitonin receptor

CTR-ir:

CTR immuno-reactivity

CVD:

Cardiovascular disease

ELISA:

Enzyme-linked immunosorbant assay

FACS:

Fluorescence activated cell sorting

Gb R:

Gamma amino butyric acid receptor

GDNF:

glial cell-derived neurotrophic factor

GFAP:

Glial fibrilliary acidic protein

GFR:

GDNF-family receptor

GPCR:

G-protein coupled receptors

HMEC:

Human microvessel endothelial cells

IF:

Immunofluorescence

IHC:

Immunohistochemistry

ISH:

In situ hybridization

[125I]-sCT:

[125I]-iodine labeled salmon calcitonin

MAb:

Monoclonal antibody

NFkappaβ:

Transcription factor

PAb:

Polyclonal antibody

PACAP:

Pituitary adenylyl cyclase activating peptide

PAC 1:

PACAP selective receptor

PCR:

Polymerase chain reaction

PNS:

Peripheral nervous system

PTH:

Parathyroid hormone

RAMP:

Receptor activity modifying protein

RANK:

Receptor activator of NFkappaβ

RANKL:

RANK ligand

RET:

(RE-arranged during Transfection) receptor tyrosine kinase

VEGFR:

Vascular epithelial growth factor receptor

VIP:

Vasoactive intestinal peptide

VPAC R:

VIP/PACAP receptor

WB:

Western blot

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Authors and Affiliations

  1. Departments of Medicine and Cardiology, University of Melbourne, Lance Townsend Building, Level 10, Austin Health, Studley Road, Victoria, Australia

    P.J. Wookey, A. Zulli & D. L. Hare

  2. Department of Medicine, University of Hong Kong, Hong Kong, China

    C. Lo & A. Y. Leung

  3. Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Victoria, Australia

    A. P. Schwarer

  4. School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia

    I. A. Darby

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  1. P.J. Wookey
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  2. A. Zulli
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  3. C. Lo
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  4. D. L. Hare
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  5. A. P. Schwarer
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  6. I. A. Darby
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  7. A. Y. Leung
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Correspondence to P.J. Wookey .

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  1. School of Biological Sciences, University of Auckland, Symonds St. 9, Auckland , 1142, New Zealand

    Deborah L. Hay

  2. University of Auckland, Symonds Street 3A, Auckland, 1142, New Zealand

    Ian M. Dickerson

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Wookey, P. et al. (2010). Calcitonin Receptor Expression in Embryonic, Foetal and Adult Tissues: Developmental and Pathophysiological Implications. In: Hay, D., Dickerson, I. (eds) The calcitonin gene-related peptide family. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2909-6_13

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